In the realm of pharmaceutical formulations, the quest for efficient and reliable drug delivery systems has led to significant advancements. Among these, CELLETS®—highly spherical microcrystalline cellulose (MCC) pellets—have emerged as a…

The patent application titled “Modified Release Gamma-Hydroxybutyrate (GHB) Formulations Having Improved Pharmacokinetics” (US20240148685) focuses on improving the delivery of GHB, a substance used for treating sleep disorders like…

The hydrodynamic behaviour of the spouted bed in the pharmaceutical industries has been found to be less addressed. The present paper has focused on the hydrodynamic characteristics of a spouted bed where the Cellets™ (Ph.Eur./USP) is…

Cellets are inert starter cores made of microcrystalline cellulose (MCC). They play an important role in new formulations of solid dosage forms. As a carrier system for actives, the chemical inertness and surface smoothness are crucial…

The main objective of this study was to investigate the effect of microcrystalline cellulose (MCC) spheres (Cellets) size effect on the powder properties to assess the possible impact of the Cellets’ size on the powder behaviour in the…

The main objective of this study was to investigate the effect of microcrystalline cellulose (MCC) spheres (Cellets) size effect on the powder properties to assess the possible impact of the Cellets’ size on the powder behaviour in the…

Abstract Orodispersible films (ODFs), easy to administer, flexible in dosage, and free of choking and aspiration risks, have drawn widespread attention as pediatric formulations. However, it is a great challenge to endow ODFs with…

Abstract The aim of this study was to investigate the feasibility of coated pellet formulation by high shear mixing of drug pellets and polymer particles without solvent or heat. First, drug-layered pellets were prepared by high shear…