Ternary Amorphous Solid Dispersions Containing a High-Viscosity Polymer and Mesoporous Silica Enhance Dissolution Performance

13. December 2020

The aim of this study was to evaluate the benefits of a ternary amorphous solid dispersion (ASD) that was designed...

Core beads with different types of Avicel

Development of High Drug Load Multiparticulate Beads Using an Extrusion-Spheronization Process

11. December 2020

Purpose Drug X is high solubility, high permeability BCS/DCS I small molecule drug. High dose and potential pediatric indication required...

Thiolated and PEGylated silica nanoparticle delivery to hair follicles

3. December 2020

Targeting drug delivery to hair follicles is valuable to treat conditions such as alopecia’s and acne, and this shunt route...

Empty mesoporous silica particles significantly delay disease progression and extend survival in a mouse model of ALS

28. November 2020

Amyotrophic lateral sclerosis (ALS) is a devastating incurable neurological disorder characterized by motor neuron (MN) death and muscle dysfunction leading...

graphical abstract of The Influence of Solidification on the in vitro Solubilisation of Blonanserin Loaded Supersaturated Lipid-Based Oral Formulations

The Influence of Solidification on the in vitro Solubilisation of Blonanserin Loaded Supersaturated Lipid-Based Oral Formulations

21. November 2020

Supersaturated silica-lipid hybrids have previously demonstrated improved in vitro solubilisation and in vivo oral bioavailability of poorly water-soluble drugs, however were only fabricated using...

Fabrication of large pore mesoporous silica microspheres by salt-assisted spray-drying method for enhanced antibacterial activity and pancreatic cancer treatment

16. November 2020

Large-pore mesoporous silica (LPMS) microspheres with tunable pore size have received intensive interest in the field of drug delivery due...

Paclitaxel-Loaded Colloidal Silica and TPGS-Based Solid Self-Emulsifying System Interferes Akt/mTOR Pathway in MDA-MB-231 and Demonstrates Anti-tumor Effect in Syngeneic Mammary Tumors

15. November 2020

A solid self-emulsifying drug delivery system (SEDDS) of paclitaxel (PTX) was developed that could enhance its oral bioavailability and neutralize...

Co-administration of mini-tablets orlistat and xanthan gum

Anti-obesity effect with reduced adverse effect of the co-administration of mini-tablets containing orlistat and mini-tablets containing xanthan gum: In vitro and in vivo evaluation

28. October 2020

The purpose of this study was to develop an oral dosage form of orlistat for the treatment of obesity with...

Overcoming the Solubility Barrier of Ibuprofen by the Rational Process Design of a Nanocrystal Formulation

21. October 2020

Wet media milling, coupled with spay drying, is a commonly proposed formulation strategy for the production and solidification of nanosuspensions...

Development of piroxicam mini-tablets enabled by spherical cocrystallization

16. October 2020

We examined the potential of the spherical cocrystallization (SCC) technology in simultaneously enhancing tablet manufacturability and dissolution of poorly soluble...

Silica