Sodium Stearyl Fumarate

Abstract Background/Objectives: Poor aqueous solubility of active pharmaceutical ingredients (APIs) remains a critical barrier to effective oral formulation. This study...

Formulation Challenges in Low-Dose Fixed-Dose Combinations Developing fixed-dose combination (FDC) therapies presents unique formulation challenges, particularly when one active pharmaceutical...

Abstract The presented work investigates critical aspects of rational formulation design through machine learning (ML) methodology to identify essential patterns...

Abstract Background: The compaction of formulation blends is a critical stage in pharmaceutical tablet manufacturing, particularly when drug substances or...

PMC Isochem, have developed four Vitamin E TPGS premixes ( see the brochure below) with 4 common excipients used as...

Abstract Silicification of microcrystalline cellulose (MCC) has previously been shown to have positive effects on the powder’s flowability and tabletability...

Abstract Granulation is a major focus of pharmaceutical R&D, as a key step in the development of solid pharmaceuticals. In...

Abstract Objectives The study aimed to combine instant-release and mini-tablet methodologies to develop novel orally disintegrating mini-tablets (ODMTs) for a...

Abstract Nitrosamine impurities have provoked numerous global medicine recalls due to their possible presence during drug manufacturing or storage. Regarding...

Abstract Improving the manufacturability of drug formulations via direct compression has been of great interest for the pharmaceutical industry. Selecting...