New Vitamin E TPGS- Premixes by PMC Isochem

PMC Isochem, have developed four Vitamin E TPGS premixes ( see the brochure below) with 4 common excipients used as support ( MCC, Mannitol, Stearyl Fumarate and Copovidone).

Pilots have been realized with success which means materials for sampling are available.

See the brochure contents here and find the full brochure below: 

VITAMIN E TPGS

Pharma (NF) and Food Grade

Tocophersolan or D-α-tocopheryl polyethylene glycol succinate (Vitamin E TPGS or TPGS) was developed 75 years ago by Eastman Kodak as a watersoluble form of vitamin E, has been approved by FDA as a safe adjuvant and is now widely used in drug delivery systems for marketed drugs. Its surfactant properties triggered the interest of drug formulation developers before it steadily moved into the toolbox of pharmaceutical drug delivery innovators.

The biological and physicochemical properties of TPGS provide multiple advantages for its applications in drug delivery like high biocompatibility, enhancement of drug solubility, improvement of drug permeation and selective antitumor activity.

TPGS PREMIXES

Functional excipients with unique properties and new easy-handling solid forms

D-alpha-tocopheryl polyethylene glycol succinate (TPGS) is widely recognized for its pharmaceutical applications; however, its physical state as a waxy solid at room temperature poses significant challenges for industrial handling and formulation. This inherent property necessitates heating to convert TPGS into a workable viscous liquid, requiring specialized equipment and knowledge of wax handling, and increasing operational complexity. Additionally, handling TPGS at elevated temperatures introduces safety concerns, further limiting its widespread adoption in pharmaceutical and industrial applications.

This is changed throught the new TPGS Premixes, which are available as a free flowing powder.

ISODEL TPGS MCC

is a premix composed with TPGS supported on microcrystalline cellulose including a minor amount of silica.

ISODEL TPGS SF

is a premix composed with TPGS supported on sodium stearyl fumarate including a minor amount of silica.

ISODEL TPGS KOL

is a premix composed with TPGS supported on copovidone

ISODEL TPGS MANI

is a premix composed with TPGS supported on mannitol

50 years
expertise & experience
in complex organic molecule syntheses

3 c-GMP
manufacturing sites
around Paris, France

From
lab to multi tons
productions

See the full  brochure on TPGS Premixes here

(click the picture to download the brochure)

Source: PMC Isochem technical brochure Your partner for functional excipients Isodel

If you have any questions or need a sample by PMC Isochem, please feel free to contact us: