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Abstract To prevent contamination by nitrosamine drug substance-related impurities (NDSRIs) in solid dosage forms, the modeling of drug nitrosation reactions...
Abstract Polymeric amorphous solid dispersions (ASDs) are frequently used to improve solubility and oral bioavailability of poorly water-soluble drugs. The...
Abstract Ezetimibe is a cholesterol absorption inhibitor widely used in the treatment of dyslipidemia. However, its clinical efficacy is limited...
Abstract Amorphous solid dispersions (ASDs) represent a promising formulation strategy for improving the solubility and bioavailability of poorly water-soluble drugs,...
Abstract Lornoxicam, a potent nonsteroidal anti-inflammatory drug (NSAID), suffers from poor aqueous solubility, leading to limited dissolution and variable bioavailability....
This poster was presented by Gattefossé at CRS 2025, the Annual Meeting and Exposition conference 2025 in Philadelphia, PA: Introduction...
Abstract Classical computer-aided drug design answers “Will this ligand bind?”, whereas computer-driven drug formulation answers the downstream but equally critical...
Summary Ritonavir (RTV) is an anti-HIV protease inhibitor and antiretroviral medication to treat HIV /AIDS and especially COVID-19 infection. But...
Abstract Background and purpose: Valsartan (Val), administered for hypertension, exhibits poor water solubility, resulting in low oral bioavailability. This study...
Dispersome is a solubility enhancement technology that relies on an innovative and naturally occurring excipient to develop amorphous solid dispersions...
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