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Solid Dispersion
Supercritical fluid technology as a strategy for nifedipine solid dispersions formulation: in vitro…
Abstract
Supercritical fluid technology (SFT) is an insufficiently investigated approach for the production of solid dispersions, it is environmentally acceptable and has a high potential for application in the pharmaceutical industry. The aim of this work was to formulate and characterize…
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Physicochemical reports of gliclazide-carplex solid dispersions and tablets prepared with directly…
Abstract
Objectives
The main goal of this research was to develop better tablet formulations by utilizing solid dispersions (SDs) and coprocessing excipients composite to achieve a better release rate of poor water-soluble gliclazide.
Methods
The solvent evaporation method made SDs of…
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Phase homogeneity in ternary amorphous solid dispersions and its impact on solubility, dissolution…
Abstract
As performance of ternary amorphous solid dispersions (ASDs) depends on the solid-state characteristics and polymer mixing, a comprehensive understanding of synergistic interactions between the polymers in regard of dissolution enhancement of poorly soluble drugs and subsequent…
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Comparison of Two Grafted Copolymers, Soluplus and Kollicoat IR, as Solid Dispersion Carriers of…
Arteether (ART), an antimalarial drug, belongs to BCS class II and has very low oral bioavailability. Clinically, it is given as a solution in oil by the intramuscular route. Solid dispersion in Soluplus or Kollicoat IR, two commonly used grafted copolymers, may improve its in vitro dissolution and…
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Nanocrystalline solid dispersions: an emerging approach for oral bioavailability enhancement of…
The bioavailability of lapatinib ditosylate, an active anticancer agent against breast neoplasms, is constrained by its poor bioavailability due to poor aqueous solubility. So, the study’s objective was to develop its nanocrystalline solid dispersion (NSD) in order to improve its oral…
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Enhancing Dissolution Efficiency of Ketoprofen, A Rheumatoid Arthritis Pain Management Drug, through…
This article is part of the issue: PROCEEDINGS OF THE INTERNATIONAL CONFERENCE OF THE CHINESE RHEUMATOLOGISTS (ICCR) 25–26 November 2023
Abstract
Background
Ketoprofen (KPN) is commonly prescribed drug to alleviate pain related with rheumatoid arthritis (RA).…
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The step-wise dissolution method: An efficient DSC-based protocol for verification of predicted…
Abstract
The development of an amorphous solid dispersion (ASD) is a promising strategy for improving the low bioavailability of many poorly water-soluble active pharmaceutical ingredients (APIs). The construction of a temperature–composition (T–C) phase diagram for an API–polymer combination is…
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Sugars and Polyols of Natural Origin as Carriers for Solubility and Dissolution Enhancement
Abstract
Crystalline carriers such as dextrose, sucrose, galactose, mannitol, sorbitol, and isomalt have been reported to increase the solubility, and dissolution rates of poorly soluble drugs when employed as carriers in solid dispersions (SDs). However, synthetic polymers dominate the preparation…
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Drug Dissolution in Oral Drug Absorption: Workshop Report
Abstract
The in-person workshop “Drug Dissolution in Oral Drug Absorption” was held on May 23–24, 2023, in Baltimore, MD, USA. The workshop was organized into lectures and breakout sessions. Three common topics that were re-visited by various lecturers were amorphous solid dispersions (ASDs),…
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Design of Redispersible High-Drug-Load Amorphous Formulations: Impact of Ionic vs Nonionic…
Amorphous solid dispersions (ASDs) are an enabling formulation approach used to enhance bioavailability of poorly water-soluble molecules in oral drug products. Drug-rich amorphous nanoparticles generated in situ during ASD dissolution maintain supersaturation that drives enhanced absorption.…
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