Solid Dispersion

Abstract Classical computer-aided drug design answers “Will this ligand bind?”, whereas computer-driven drug formulation answers the downstream but equally critical...

Summary Ritonavir (RTV) is an anti-HIV protease inhibitor and antiretroviral medication to treat HIV /AIDS and especially COVID-19 infection. But...

Abstract Background and purpose: Valsartan (Val), administered for hypertension, exhibits poor water solubility, resulting in low oral bioavailability. This study...

Dispersome is a solubility enhancement technology that relies on an innovative and naturally occurring excipient to develop amorphous solid dispersions...

Abstract This study investigates the use of an octenylsuccinate-modified dendrimer-like biopolymer (OS-DLB) as a carrier matrix in the formulation of...

Abstract This study investigates the solubility and miscibility of ibuprofen (IBU) with four pharmaceutical polymers, KOLVA64®, KOL17PF®, HPMCAS, and Eudragit®...

Abstract Traditional extemporaneous compounding methods of solid oral dosage forms required in early-stage studies are laborious, and the drug’s solid...

Abstract The number of newly developed substances with poor water solubility continually increases. Therefore, specialized formulation strategies are required to...

Abstract The development of solid dispersions (SDs) has gained increased attention in recent decades, leading to successful delivery systems for...

Abstract There is a growing industrial need for quick and early screening of amorphous solid dispersions (ASDs). While new technologies...