Solubility Enhancement

Abstract Metaxalone is a muscle relaxant. However, its low solubility limits its bioavailability. Drug cocrystal technology can improve the physicochemical...

Abstract This study explores the impact of drug loading (DL) on the physical stability, dissolution performance, and micellisation behaviour of...

Abstract The aim of this study was to develop a once-daily controlled-release (CR) apixaban (APX) formulation that enhances bioavailability through...

Abstract Mangiferin, a natural bioactive compound with multiple physiological functions, faces limitations in its oral bioavailability due to poor stability...

Abstract Lung-targeted drug delivery has emerged as one of the most promising strategies for treating lung cancer, enhancing local drug...

Introduction to Micro environmental pH-Modulated Dissolution Micro environmental pH-modulated dissolution describes an approach in controlled oral drug delivery where the...

Abstract Amorphous solid dispersion (ASD) is a widely adopted strategy to enhance the solubility of poorly water-soluble drugs. However, disintegration...

Abstract Poor solubility of curcumin (Cur) has greatly limited its applications. To establish Cur amorphous solid dispersions (Cur ASDs) with...

Abstract Background/Objectives: Canagliflozin (CFZ) is the first sodium glucose co-transporter 2 (SGLT-2) inhibitor and is characterized by poor water solubility...

Overview of Functional Core Use in Drug Delivery A tartaric acid starter core for extended release formulations serves as a functional nucleus...