Dispersome Makes Your Drugs Soluble

3. September 2025

Dispersome is a solubility enhancement technology that relies on an innovative and naturally occurring excipient to develop amorphous solid dispersions...

Overcoming corneal barriers: Posaconazole loaded cationic surfactant vesicles for enhanced ocular permeability and anti-fungal efficacy

31. August 2025

Abstract Posaconazole (PCZ) is a broad spectrum anti-fungal drug approved by FDA and currently used off-label for the treatment of...

Enhancing Drug Solubilization Using a Surface-modified Edible Biopolymer Through Hot Melt Extrusion: A Design Space Methodology

28. August 2025

Abstract This study investigates the use of an octenylsuccinate-modified dendrimer-like biopolymer (OS-DLB) as a carrier matrix in the formulation of...

Advancing amorphous solid dispersions through empirical and hybrid modeling of drug–polymer solubility and miscibility: A case study using Ibuprofen

22. August 2025

Abstract This study investigates the solubility and miscibility of ibuprofen (IBU) with four pharmaceutical polymers, KOLVA64®, KOL17PF®, HPMCAS, and Eudragit®...

Solubilization of Azelnidipine in TPGS Micelles: Structural Insights, Micellar Stability, and Sustained Drug Release Behavior

11. August 2025

Abstract Polyethoxylated (PEO)-based nonionic surfactants, such as D-α-Tocopheryl polyethylene glycol succinate (TPGS), offer significant advantages in drug delivery due to...

Precipitation as Key Parameter for Early Oral Drug Absorption Predictions, Part I: Acquisition of critical data

6. August 2025

Abstract Despite recent advancements in the development of in vitro precipitation assays for weakly basic drugs, their relevance for predicting...

Lipid-Based Formulation in Customized Enteric Capsule for Oral GLP-1 Receptor Agonist Peptide Delivery

1. August 2025

Objectives of this study Multiple factors affect oral delivery of therapeutic peptides such as acidic and enzymatic degradation in the...

Effect of Quantitative Structural Properties and Drug Formulation in Four Cannabinoids on Their Lymphatic Transport after Enteral Administration in Rats

Effect of Quantitative Structural Properties and Drug Formulation in Four Cannabinoids (Cannabidiol, Cannabigerol, Cannabichromene, and Cannabinol) on Their Lymphatic Transport after Enteral Administration in Rats

26. July 2025

Abstract The effect of quantitative structural properties of drugs on the extent of lymphatic transport is not well understood. Our...

Hydrophilic and Amphiphilic Macromolecules as Modulators of the Physical Stability and Bioavailability of Piribedil: A Study on Binary Mixtures and Micellar Systems

13. July 2025

Abstract This study presents an innovative approach that utilizes polymers with different topologies and properties as potential matrices for the...

Olmesartan Medoxomil Nanomicelle Using Soluplus for Dissolution Enhancement: Preparation, In-vitro and Ex-vivo Evaluation

9. July 2025

Abstract The antihypertensive medication olmesartan medoxomil (OLM) is pharmacologically selective angiotensin-II receptor antagonist. Pharmaceutically speaking, OLM is a class II...

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