Browsing Category
Asahi Kasei
Study of direct compression coverage in view of design space – Ceolus UF grades
1. What is the design space?
The design space (DS) is a multidimensional combination and interaction of input variables (e.g., properties of raw materials) and process parameters that have been proven to ensure the quality of drug products. Operation within the DS is not considered a change,…
Read More...
Read More...
Comparison of Ceolus™ Grades in Continuous Manufacturing (Wet Granulation) – Continuous…
1. Introduction
Until now, batch manufacturing has been the main mode of pharmaceutical manufacture: raw materials are input and processed in a stage of the process then removed for input and process in the next stage of the sequence. However, in recent years, manufacturers have explored…
Read More...
Read More...
Effective nose-to-brain drug delivery using a combination system targeting the olfactory region in…
The nose-to-brain (N2B) pathway has garnered attention because it transports drugs directly into the brain. Although recent studies have suggested the necessity of selective drug administration to the olfactory region for effective N2B drug delivery, the importance of delivering the formulation to…
Read More...
Read More...
MCC Spheres Facilitate Precise Dissolution Profile of Controlled Release Formulations
A 100% MCC sphere, Celphere™ has high sphericity and narrow particle size distribution. Also, Celphere™ is less damaged during film coating process because of its high mechanical strength. With regard to comparison with sugar spheres, Celphere™ can prevent agglomeration during film coating process…
Read More...
Read More...
Pharmaceutical evaluation of Levofloxacin orally disintegrating tablet formulation using low…
We evaluated the pharmaceutical properties of levofloxacin (LV) in the form of an orally disintegrating tablet (LVODT) to find a new usefulness of low frequency (LF) Raman spectroscopy. LVODT contained dispersed granules with diameters in the order of several hundred micrometers, which were composed…
Read More...
Read More...
A Data-Driven Approach to Predicting Tablet Properties after Accelerated Test Using Raw Material…
The purpose of this study was to develop a model for predicting tablet properties after an accelerated test and to determine whether molecular descriptors affect tablet properties. Tablets were prepared using 81 types of active pharmaceutical ingredients, with the same formulation and three…
Read More...
Read More...
Comparison of Ceolus™ Grades – Continuous Manufacturing System “Granuformer® Gf-2050”
Comparison of Ceolus™ Grades in Continuous Manufacturing (Wet Granulation) - Continuous Manufacturing System “Granuformer® Gf-2050”
Introduction
Until now, batch manufacturing has been the main mode of pharmaceutical manufacture: raw materials are input and processed in a stage of the process then…
Read More...
Read More...
Application of unsupervised and supervised learning to a material attribute database of tablets…
The purpose of this study is to demonstrate the usefulness of machine learning (ML) for analyzing a material attribute database from tablets produced at different granulation scales. High shear wet granulators (scale 30 g and 1000 g) were used and data were collected according to the design of…
Read More...
Read More...
Comparison of Ceolus™ Grades in Continuous Manufacturing of Tablets using Direct Compression
1. Introduction
The introduction of continuous manufacturing of tablets has been gaining momentum, because it offers reductions in development and manufacturing costs and time and improved reliability of quality assurance.
In this study, grades of Ceolus™, microcrystalline cellulose (MCC) in…
Read More...
Read More...
Preparation of sustained-release tablets using a solventless-mixing tablet coating technique:…
The aim of this study was to produce sustained-release tablets by V-shaped blending of polymer and tablets without using solvents or heating, and we investigated the design of polymer particles with high coating performance by modifying the structure of the particles using sodium lauryl sulfate.…
Read More...
Read More...