Continuous twin screw granulation: Robustness of lactose/MCC-based formulations

19. August 2020

In recent years, significant progress has been made in the field of continuous twin screw granulation. However, only limited knowledge...

Introduction of the energy to break an avalanche as a promising parameter for powder flowability prediction

2. August 2020

Dynamic avalanche testing is a newer method useful even with cohesive powder samples. To evaluate flow properties of pharmaceutical powder...

Quantification of surface composition and surface structure of inhalation powders using TOF-SIMS

27. July 2020

A multivariate TOF-SIMS methodology has been developed and applied to quantify surface composition and chemical distribution for dry powder blends....

Tabletting Solid Dispersions of Bicalutamide Prepared Using Ball-milling or Supercritical Carbon Dioxide: The Interrelationship between Phase Transition and In-vitro Dissolution

24. July 2020

The studies were aimed at formulating tablets containing bicalutamide-PVP K-29/32 solid dispersions and accessing the interrelationships between the properties of...

A Precise Prediction Method for the Properties of API-Containing Tablets Based on Data from Placebo Tablets

5. July 2020

We previously reported a novel method for the precise prediction of tablet properties (e.g., tensile strength (TS)) using a small...

Sublingual tablets containing spray-dried carvedilol-loaded nanocapsules: development of an innovative nanomedicine

25. June 2020

The aim of this study was to propose the use of spray-dried mucoadhesive carvedilol-loaded nanocapsules in the formulation of sublingual...

A shear cell study on oral and inhalation grade lactose powders

29. May 2020

Shear cell tests have been conducted on twenty different lactose powders, most of which commercially available for oral or inhalation...

In-line temperature measurement to improve the understanding of the wetting phase in twin-screw wet granulation and its use in process development

29. May 2020

Wetting is the initial stage of wet granulation processes during which the first contact between the powder and the liquid...

Free Whitepaper – Lactose properties in 3D powder bed printing

26. May 2020

The whitepaper shows results of tested 20 lactose grades in 3D powder bed printing. The primary objective of this study...

Lactose properties and behavior in 3D powder bed printing

27. April 2020

Working with the Netherlands Organization for Applied Scientific Research (TNO), DFE Pharma tested 20 lactose grades in 3D powder bed...

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