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Fuji Chemical
Application of the Gradient boosted tree approach for thin film classification based on…
Introduction
Thin films are polymeric strips that disintegrate in the oral cavity and consist of a film-forming agent and an active pharmaceutical ingredient (API). Generally, thin films disintegrate within seconds, but their composition can be modified to allow slower disintegration and release of…
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Formulation, characterization, pharmacokinetics and antioxidant activity of phloretin oral granules
Phloretin (PHL), a flavonoid of the dihydrogen chalcone class, is reported to have low oral bioavailability due to its poor solubility and absorption. A common approach to enhance the solubility of such flavonoids is solubilization in a polymeric or lipidic matrix which would help in enhance…
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Co-Dispersion Delivery Systems with Solubilizing Carriers Improving the Solubility and Permeability…
Cannabinoids: cannabidiol (CBD), cannabidiolic acid (CBDA), and cannabichromene (CBC) are lipophilic compounds with limited water solubility, resulting in challenges related to their bioavailability and therapeutic efficacy upon oral administration. To overcome these limitations, we developed…
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A Comparative Study on Cyclodextrin Derivatives in Improving Oral Bioavailability of Etoricoxib as a…
Etoricoxib, as a model drug, has a poor solubility and dissolution rate. Cyclodextrin derivatives can be used to solve such a problem. A comparative study was run on three cyclodextrin derivatives, namely β-CD, HP β-CD, and SBE β-CD, to solve the drug problem through the formulation of solid…
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Mitigating Nitrosamine Risks in Drug Products: Fuji Chemical Offers a Low-Risk Solution with…
See the latest issue of Fuji Chemical Industries Technical Newsletter: It presents Fujicalin®, a low-risk solution for mitigating nitrosamine risks in drug products.
Mitigating Nitrosamine Risks in Drug Products: Fuji Chemical Offers a Low-Risk Solution with Fujicalin®
Nitrosamine impurities…
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Development and optimization of Ropinirole loaded self-nanoemulsifying tablets
Background
The present research work aims to develop a Ropinirole-loaded self-Nanoemulsifying Drug Delivery system. Ropinirole has limited oral bioavailability due to substantial first-pass metabolism, which ultimately results in poor oral bioavailability and reduces plasma drug concentration and…
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Development, recent advances, and updates in binary, ternary co-amorphous systems, and ternary solid…
Binary co-amorphous systems (CAMS) are a type of solid dispersion containing an active pharmaceutical ingredient (API) and small molecule excipients. The properties of these substances make them novel and a very demanding aspect of pharmaceutical research because they improve solubility, physical…
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Development and pharmacokinetic evaluation of Neusilin® US2-based S-SNEDDS tablets for bosentan:…
The study reported here aimed to develop and optimize the S-SNEDDS tablet of bosentan (BOS) and to investigate its pharmacokinetic and biodistribution properties. The BOS-loaded SNEDDS have been developed and characterized in a previous study. The BOS-loaded SNEDDS formulation was converted to…
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Formulation Development and Evaluation of Solid Self Microemulsifying Drug Delivery System of…
This study aimed to develop a self-micro emulsifying drug delivery system (SMEDDS) for poorly soluble azelnidipine using Capryol 90 as the oil, Tween 80 as the surfactant, and transcutol-HP as the co-surfactant. A factorial design was used to optimize the formulation, and Neusilin UFL2 was used as…
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Unveiling Neusilin® US2’s Prowess: Resolving Oily API Challenges in Contrast to Other Common…
Neusilin® US2 by Fuji Chemical Industries is a synthetic, amorphous form of Magnesium Aluminometasilicate with a neutral pH that can be used in both direct compression and wet granulation of solid dosage forms. Oily APIs affect flowability, compressibility, and disintegration times, thereby posing…
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