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Pfanstiehl
Preparation of antibody-loaded protein microbeads for pulmonary delivery via Shirasu porous glass…
Reversible protein precipitates (protein microbeads) have been developed using Shirasu porous glass (SPG) membrane emulsification. Microbeads have a mean size of a few micrometers (2–5 μm), and their formation is reversible upon rehydration. Their feasibility was examined as dry powders for…
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Inhaled dry powder liposomal azithromycin for treatment of chronic lower respiratory tract infection
A dry powder inhaled liposomal azithromycin formulation was developed for the treatment of chronic respiratory diseases such as cystic fibrosis and bronchiectasis. Key properties including liposome size, charge and encapsulation efficiency powder size, shape, glass transition temperature (Tg), water…
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Reversible protein complexes as a promising avenue for the development of high concentration…
Abstract
High concentration formulations have become an important pre-requisite in the development of biological drugs, particularly in the case of subcutaneous administration where limited injection volume negatively affects the administered dose. In this study, we propose to develop high…
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Trehalose-releasing nanogels: A step toward a trehalose delivery vehicle for autophagy stimulation
Trehalose has been widely studied as a treatment for a variety of human disorders due to its ability to stimulate autophagy. Trehalose, however, is poorly adsorbed and is hydrolyzed in the intestinal mucosa, and oral delivery requires relatively high doses to induce autophagy. The parenteral…
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Simultaneous Spray Drying for Combination Dry Powder Inhaler Formulations
Spray drying is a particle engineering technique used to manufacture respirable pharmaceutical powders that are suitable for delivery to the deep lung. It is amenable to processing both small molecules and biologic actives, including proteins. In this work, a simultaneous spray-drying process,…
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Understanding Heat Transfer During the Secondary Drying Stage of Freeze Drying: Current Practice and…
Currently, there is a lack of robust models for secondary drying with comparable accuracy and flexibility as primary drying models. In order to better understand heat transfer during secondary drying, sucrose and mannitol solutions were freeze-dried in vials in a lab-scale lyophilizer under various…
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Formulation Development and Improved Stability of a Combination Measles and Rubella Live-Viral…
Measles (Me) and rubella (Ru) viral diseases are targeted for elimination by ensuring a high level of vaccination coverage worldwide. Less costly, more convenient MeRu vaccine delivery systems should improve global vaccine coverage, especially in low – and middle – income countries (LMICs). In this…
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Carboxymethyl-β-glucan/chitosan nanoparticles: new thermostable and efficient carriers for antigen…
In the last few decades, nanotechnology has emerged as an important tool aimed at enhancing the immune response against modern antigens. Nanocarriers designed specifically for this purpose have been shown to provide protection, stability, and controlled release properties to proteins, peptides, and…
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Organic Solution Advanced Spray-Dried Microparticulate/Nanoparticulate Dry Powders of Lactomorphin…
The purpose of this study was to formulate Lactomorphin (MMP2200) in its pure state as spray-dried(SD) powders, and with the excipient Trehalose as co-spray-dried(co-SD) powders; for intranasal and deep lung administration with Dry Powder Inhalers (DPI). Lactomorphin is a glycopeptide which was…
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On the particle formation of leucine in spray drying of inhalable microparticles
The particle formation of L-leucine, a dispersibility-enhancing amino acid used in the spray drying of inhalable pharmaceutical aerosols, was extensively studied using three experimental methods, and the results were interpreted with the aid of theory. A comparative-kinetics electrodynamic balance…
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