Impact of co-processed excipient particles solidity and circularity on critical quality attributes of orodispersible minitablets

6. April 2021

The selection of appropriate functional co-processed excipient (CPE) is a crucial stage in orodispersible minitablets (ODMTs) development. This paper aimed...

Development of a Solid Supersaturable Micelle of Revaprazan for Improved Dissolution and Oral Bioavailability Using Box-Behnken Design

21. February 2021

Purpose: To enhance the oral bioavailability of revaprazan (RVP), a novel solid, supersaturable micelle (SSuM) was developed. Methods: Surfactants and...

Dynamic vapor sorption of (a) powder blends containing different binders or no binder (n = 1) and (b) of different pure binders (n = 1). HPC SSL-SFP and HPC SSL are overlapping. HPC: hyprolose.

Evaluation of Binders in Twin-Screw Wet Granulation

15. February 2021

The binders povidone (Kollidon 30), copovidone (Kollidon VA64), hypromellose (Pharmacoat 606), and three types of hyprolose (HPC SSL‑SFP, HPC SSL,...

Relevance of Liquid-Liquid Phase Separation of Supersaturated Solution in Oral Absorption of Albendazole from Amorphous Solid Dispersions

13. February 2021

Amorphous solid dispersion (ASD) is one of the most promising formulation technologies for improving the oral absorption of poorly soluble...

Co-Processed Excipients for Dispersible Tablets—Part 2: Patient Acceptability

11. February 2021

Palatability and patient acceptability are critical attributes of dispersible tablet formulation. Co-processed excipients could provide improved organoleptic profile due to...

Co-Processed Excipients for Dispersible Tablets–Part 1: Manufacturability

8. February 2021

Co-processed excipients may enhance functionality and reduce drawbacks of traditional excipients for the manufacture of tablets on a commercial scale....

graphical abstract of Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement of Poorly Soluble Drugs

Nanoporous Silica Entrapped Lipid-Drug Complexes for the Solubilization and Absorption Enhancement of Poorly Soluble Drugs

20. January 2021

This study aims to examine the contribution of nanoporous silica entrapped lipid-drug complexes (NSCs) in improving the solubility and bioavailability...

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