The effect of excipients on oral lyophilizates quality attributes
Pharmaceutical industry is constantly focused on researching patient-centered dosage forms that can maximize the therapeutic potential of an active pharmaceutical ingredient, as for example orodispersible form. The main advantage of orodispersible dosage forms is that they are suitable for patients with swallowing problems, children, geriatric, and psychiatric patients, leading to improvement in patient compliance. Orodispersible drug formulations include orodisperisble tablets, oral lyophilizates, orodispersible granules, minitablets, orodispersible films, and some less common. Oral lyophilizates are solid forms, intended either to be placed in the mouth or to be dispersed (or dissolved) in water before administration. The composition of oral lyophilizates determines their quality attributes, and generally includes binders, fillers, taste modifiers, sweeteners, and preservatives (Bjelošević Žiberna et al., 2023; Slavkova & Breitkreutz, 2015).
Our aim was to design formulations for preparation of oral lyophilizates by implementation of aggressive primary drying conditions, contributing to a smaller financial and environmental burden. The objectives were: (i) to examine the influence of glycine, and croscarmellose on the quality attributes of lyophilizates based on mannitol, gelatin, and polyvinylpyrrolidone K25; and (ii) to discover the potential of hydrolyzed gelatin in oral lyophilizates.
Download the full article as PDF here The effect of excipients on oral lyophilizates quality attributes
or read it here
Materials
Gelatin, hydrolyzed gelatin, polyvinylpyrrolidone (PVP) K25, were from Sigma-Aldrich, Germany, and glycine, mannitol, and croscarmellose were purchased from Merck, Germany
The effect of excipients on oral lyophilizates quality attributes, Maja Bjelošević Žiberna, Odon Planinšek, Pegi Ahlin Grabnar, Macedonian pharmaceutical bulletin, 69 (Suppl 1) 179 – 180 (2023), Online ISSN 1857 – 8969, DOI: 10.33320/maced.pharm.bull.2023.69.03.088
Read more on Orally Disintegrating Tablets (ODTs) here:
