granulation

1 Granulation Technology Granulation technology is commonly used in the pharmaceutical industry during solid oral dosage form development, especially in tablet and capsule manufacturing (Parikh, 2010; Shanmugam, 2015). The process commonly is used for size enlargement, where small particles are…
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Wet granulation is one of the most important unit operations in the production of pharmaceutical dosage forms. This chapter describes various wet granulation methodologies, with major focus on high-shear wet granulation (HSWG) and fluid bed granulation (FBG) processes. Current industrial…
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Quality by design (QbD) is a scientific and risk-based approach applicable throughout the product development process. The QbD principles are outlined in the ICH guidelines (Q8, Q9, and Q10) and are aimed at establishing a systematic methodology for releasing quality pharmaceutical products into the…
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Granulation, defined as a size enlargement in which small particles stick together by having a liquid bind onto their surface, plays an extremely important role in the powder-handling process. It is widely applied in particle manufacturing processes of the pharmaceuticals, food, fertilizer, forage,…
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High-shear wet granulation is a complex process that, in turn, makes scale-up a challenging task. Scale-up of high-shear wet granulation process has been studied extensively in the past with various different methodologies being proposed in the literature. This review article discusses existing…
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Granulation is a typical unit operation of particle enlargement carried out by the pharmaceutical industry to produce pharmaceutical dosage forms like tablets and capsules for over 70 years (Parikh, 2009). The purpose of wet granulation can be, but is not limited to: • Enhance the…
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Download the Poster or order a Hard Copy (Format Din A0) here The poster "From Powders to Agglomerates" gives an overview on the different process technologies and processing steps involved for each technology. It also shows the characteristics of the granules including porosity, bulk density, etc.
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Glatt Pharmaceutical Services has put together an explanatory poster covering the different technologies for agglomeration / granulation based on powders, melts and liquids. Interested to get the full poster? Send us an email or visit our booth at the 3rd European Conference on Pharmaceutics March…
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Data from wall friction testing and physical property characterization of over one hundred pharmaceutical powders, blends, and granulations has been analyzed. The analyses focused on data for stainless steel surfaces with the most common finishes for pharmaceutical powder processing equipment,…
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Spouted beds (SBs) have a long history of successful applications for preparation of solid dosage forms of pharmaceuticals. The well-known versatility of SBs, provided by different design and operational factors, and their efficient mixing of solids allow for engineering of technological…
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