Lipid based nanocarriers: Production techniques, concepts, and commercialization aspect
Over the past decade, compared to all other macromolecules lipid-based nanocarriers have proven to be an excellent carrier and delivery system for various pharmaceutical drugs of poor bioavailability. In addition to that, they exhibit exceptional qualities such as minimal toxicity, economical scale-up production, great biocompatibility, and high drug loading efficiency. In this study, we have discussed the various types of lipid nanoparticles, such as liposomes, nanostructured lipid carriers, solid lipid nanoparticles, and lipid polymer hybrid nanoparticles. We have also conferred in detail, the composition, shape and size, methods of preparation, advantages, and certain limitations associated with these lipid-based nanocarriers. Additionally, we have exclusively accounted for several examples of lipid-based nanomedicines that have either been approved and commercialized or are under the different phases of clinical trials. The current review overall focuses on the up-to-date research that has recently been published in view of developing lipid-based nanocarriers for various biological applications, including gene therapy, breast cancer therapy, and vaccine development.
Rahul Kumar, Daphika S. Dkhar, Rohini Kumari, Divya, Supratim Mahapatra, Vikash Kumar Dubey, Pranjal Chandra,
Lipid based nanocarriers: Production techniques, concepts, and commercialization aspect,
Journal of Drug Delivery Science and Technology, Volume 74, 2022, 103526, ISSN 1773-2247,
https://doi.org/10.1016/j.jddst.2022.103526.