Abstract Background. Amoxicillin trihydrate possesses poor solubility, compressibility, and flow behavior. Amorphous solid dispersion prepared by spray drying could solve all three problems at the same time. Objective. To prepare amorphous…

With an increasing concern of global antimicrobial resistance, the efforts to improve the formulation of a narrowing library of therapeutic antibiotics must be confronted. The liposomal encapsulation of antibiotics using a novel and…

Rectal drug administration could offer advantages in the delivery of medicines for children by avoiding swallowability issues, improving stability and enabling administration by caregivers. This study aimed to evaluate the rectal…

In this paper, rectal absorption and tissue tolerance of amoxicillin sodium (AS) suppositories prepared in a hydrophilic base, polyethylene glycol (PEG) or lipophilic base, Suppocire® NA 15 (SNA 15), were investigated. Following in vitro …

Gastro-retentive drug delivery systems (GRDDS) provide prolonged drug release in the stomach for the treatment of some diseases located in the gastric area, and can improve patient compliance by reducing the required dosing frequency. In…

Multilayer/bilayer tablets have been applied for the formulation of incompatible components for compound preparations, but more often they are used to modify drug release. The objective of this study was to explore the feasibility…

Abstract The bacterium Helicobacter pylori (H. pylori) represents a major risk factor associated with the development of gastric cancer. The anti-oxidant curcumin has been ascribed many benefits to human health, including bactericidal…

See an overview of the IOI Oleo specialties for Veterinary Applications. They are used for companion as well as for farm animals in following uses: • Injectables - SC and IM • Infusions - IV • Oral (e.g. paste, drench) • Pour-on…

IOI Oleo GmbH - EXCIPIENTS FOR INJECTABLE FORMULATIONS For injectable formulations, the selection of a pure excipient is key to ensure constant drug product quality, stability, efficacy, and finally patient safety. IOI Oleo offers…