This case study aimed to evaluate the feasibility of forming equimolar co-amorphous drug-phospholipid systems by different preparation methods. Indomethacin (IND) was chosen as a model drug and combined with three phospholipids of natural…

The aim of this work was to study the possibility to use SepitrapTM as a carrier for the formulation of amorphous solid dispersions by HME (hot melt extrusion) processing aiming solubility enhancement of poorly water-soluble drugs.…

The feasibility of co-amorphous systems to be wet granulated together with microcrystalline cellulose (MCC) was investigated. Solid state and molecular interactions were analysed for various co-amorphous drug-amino acid formulations of …

This work developed immediate-release hot melt extruded pellets containing the poorly aqueous soluble drug Indomethacin with five different screw configurations for oral application. Moreover, numerical simulation concerning residence time…

Ocular chemical burns are prevalent injuries that must have immediate and effective treatment to avoid complications. Aiming to improve bioavailability and efficacy, a poloxamer-based thermoresponsive in-situ gelling system containing…

The aim of this study was to investigate the preparation of co-amorphous mixture-layered pellets using solventless pelletization and amorphization using a high shear granulator (as suggested in the first part of this study) by high shear…

The aim of the current study was to investigate the feasibility of solventless amorphization and pelletization using a high shear granulator, to produce amorphous drug-layered pellets by simply mixing drug crystals and inactive spheres…

Indomethacin (IND) is topically administered for the treatment of the anterior segment diseases such as conjunctivitis, uveitis, and inflammation prevention for post-cataract surgery, as well as posterior segment diseases as macular edema.…

The present study evaluates the effect of kosmotropic inorganic salts in the disintegration time and the in vitro dissolution behavior of tablets containing polyvinylpyrrolidone (PVP)-based amorphous solid dispersions (ASDs). Specifically,…

Current study aimed to develop a spray-dried powder containing indomethacin (IND)-loaded polymeric micelles which can be administered perorally as a dissolved powder to enhance the drug release and permeability of the active substance. The…