Browsing Category
Chitosan
Nanosized Drug Delivery Systems to Fight Tuberculosis
Tuberculosis (TB) is currently the second deadliest infectious disease. Existing antitubercular therapies are long, complex, and have severe side effects that result in low patient compliance. In this context, nanosized drug delivery systems (DDSs) have the potential to optimize the treatment’s…
Read More...
Read More...
Towards the development of a biorelevant in vitro method for the prediction of nanoemulsion…
Ophthalmic oil-in-water nanoemulsions (NEs) are a complex technological platform, representing an advancement in the treatment of dry eye disease. In addition to enabling the incorporation of poorly soluble active pharmaceutical ingredients (APIs), NEs provide prolonged residence time of APIs and…
Read More...
Read More...
Optimising nasal powder drug delivery – Characterisation of the effect of excipients on drug…
The nasal physiology offers great potential for drug delivery but also poses specific challenges, among which the short residence time of applied drugs is one of the most striking. Formulating the drug as powder and using functional excipients are strategies to improve drug absorption. As nasal…
Read More...
Read More...
3D-printed long-acting 5-fluorouracil implant to prevent conjunctival fibrosis in glaucoma
Abstract
Objectives
To develop a sustained release 5-fluorouracil (5-FU) implant by three-dimensional (3D) printing to effectively prevent conjunctival fibrosis after glaucoma surgery.
Methods
3D-printed implants composed of polycaprolactone (PCL) and chitosan (CS) were…
Read More...
Read More...
Transferrin-modified chitosan nanoparticles for targeted nose-to-brain delivery of proteins
Nose-to-brain delivery presents a promising alternative route compared to classical blood–brain barrier passage, especially for the delivery of high molecular weight drugs. In general, macromolecules are rapidly degraded in physiological environment. Therefore, nanoparticulate systems can be used to…
Read More...
Read More...
Recent approaches for enhancing the performance of dissolving microneedles in drug delivery…
Dissolving microneedles (dMNs) are promising versatile drug delivery systems for the transdermal delivery of numerous drugs, enabling their use in a wide range of biomedical and pharmaceutical applications. Being made of water-soluble polymers, dMNs own several advantages, including fast dissolution…
Read More...
Read More...
Pharmaceutical polymers and P-glycoprotein: Current Trends and Possible Outcomes in Drug Delivery
Drug resistance is considered a key reason behind the failure of therapeutic medications for several chronic diseases, including hypertension, cancer therapeutics, and antimicrobial agents. Among the strategies used to overcome drug resistance are therapeutic targeting of other factors involved in…
Read More...
Read More...
Advances in Formulation and Manufacturing Strategies for the Delivery of Therapeutic Proteins and…
Therapeutic proteins and peptides (TPPs) are increasingly favoured above small drug molecules due to their high specificity to the site of action and reduced adverse effects resulting in increased use of these agents for medical treatments and therapies. Consequently, there is a need to formulate…
Read More...
Read More...
Clarithromycin and Pantoprazole Gastro-Retentive Floating Bilayer Tablet for the Treatment of…
Bilayer/multilayer tablets have been introduced to formulate incompatible components for compound preparations, but they are now more commonly used to tailor drug release. This research aimed to formulate a novel gastro-retentive tablet to deliver a combination of a fixed dose of two drugs to…
Read More...
Read More...
Development, in vitro Evaluation, and in vivo Study of Adhesive Buccal Films for the Treatment of…
Objective: Development and evaluation of bucco-adhesive films of Gliclazide for pediatric use.
Methods: Sixteen films were formulated using a different combination of Gelatin, Hydroxy propyl methyl cellulose (HPMC), polyvinyl alcohol, Hydroxy propyl cellulose (HPC), chitosan, polyethylene glycol,…
Read More...
Read More...