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Chitosan
Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications
Microneedle (MNs) technology is a recent advancement in biomedical science across the globe. The current limitations of drug delivery, like poor absorption, low bioavailability, inadequate skin permeation, and poor biodistribution, can be overcome by MN-based drug delivery. Nanotechnology made…
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Statistical optimization of voriconazole nanoparticles loaded carboxymethyl chitosan-poloxamer based…
The research study reflects the development of novel voriconazole (VCZ) loaded nanoparticles (NPs) for prolonged delivery for the management of ocular diseases. The in situ ophthalmic gel was prepared by incorporating NPs into carboxymethyl chitosan (CMCh) and poloxamer. The central composite design…
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Harnessing the Antibacterial Properties of Fluoridated Chitosan Polymers against Oral Biofilms
Dental caries are a worldwide endemic chronic disease affecting people of all ages. Due to the limitations of daily used oral hygiene products, there is an unmet need for new, effective, safe, and economic oral products. We have recently demonstrated that N-(2(2,6-diaminohexanamide)-chitosan (CS3H…
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Carbohydrates Used in Polymeric Systems for Drug Delivery: From Structures to Applications
Abstract
Carbohydrates, one of the most important compounds in living organisms, perform numerous roles, including those associated with the extracellular matrix, energy-related compounds, and information. Of these, polymeric carbohydrates are a class of substance with a long history in drug…
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Development of a potential anti-cancer pulmonary nanosystem consisted of chitosan-doped LeciPlex…
A novel self-assembled lecithin-based cationic nanocarrier (LeciPlex) doped with chitosan was prepared to improve Resveratrol solubility and anticancer efficacy. Using on a machine learning method based on regression analysis, LP5 (composed of lecithin, Peceol® and chitosan) was selected as the…
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Influence of spray-drying process on properties of chitosan/xanthan gum polyelectrolyte complexes as…
Polyelectrolyte complexes (PECs) are attractive carriers with recognized potential to enhance oral delivery of poorly soluble high-dosed low-molecular-weight drugs. The formulation of solid oral dosage forms requires the drying of PECs, which may affect their physicochemical and biopharmaceutical…
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Enhancing Stability and Mucoadhesive Properties of Chitosan Nanoparticles by Surface Modification…
Background: The present study aimed to fabricate surface-modified chitosan nanoparticles with two mucoadhesive polymers (sodium alginate and polyethylene glycol) to optimize their protein encapsulation efficiency, improve their mucoadhesion properties, and increase their stability in biological…
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Eudragit® L100/chitosan composite thin bilayer films for intravaginal pH-responsive release of…
The high rate of HIV new infections and AIDS-related deaths each year make prevention tools still necessary today. Different dosage forms – including films – for vaginal administration of antiretroviral drugs have been developed for this purpose. Six batches of Tenofovir-loaded films were formulated…
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Electrospun poly(ω-pentadecalactone-co-ε-caprolactone)/gelatin/chitosan ternary nanofibers with…
In recent years, there is an increasing attention on biocompatible electrospun nanofibers for drug delivery applications since they provide high surface area, controlled and sustained drug release, and they mimic the extracellular matrix. In the present study, tetracycline hydrochloride (TCH)…
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Chitosan/cyclodextrin surface-adsorbed naringenin-loaded nanocapsules enhance bacterial quorum…
Pathogenic bacteria use quorum sensing (QS), a cell-to-cell communication process that uses small signalling molecules, to regulate several essential virulence factors such as bioluminescence, biofilm formation, and bacterial motility. Naringenin, a bitter and colourless flavanone ubiquitous in…
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