Material tracking in a continuous direct capsule-filling process via residence time distribution measurements

29. January 2021

Continuous production of pharmaceuticals requires traceability from the raw material to the final dosage form. With that regard, understanding the...

Continuous blending monitored and feedback controlled by machine vision-based PAT tool

24. January 2021

In a continuous powder blending process machine vision is utilized as a Process Analytical Technology (PAT) tool. While near-infrared (NIR)...

Starch Products as Candidate Excipients in a Continuous Direct Compression Line

10. January 2021

Direct compression (DC) remains the most preferred technique to produce tablets, and its effectiveness is directly influenced by raw material...

$Roll Compactor with In-line laser diffraction to measure granule size$

Implementing Feedback Granule Size Control in a Continuous Dry Granulation Line Using Controlled Impeller Speed of the Granulation Unit, Compaction Force and Gap Width

22. December 2020

In continuous manufacturing of pharmaceuticals, dry granulation is of interest because of its large throughput capacity and energy efficiency. In...

Integrated Twin-Screw Wet Granulation, Continuous Vibrational Fluid Drying and Milling: A fully continuous powder to granule line

21. December 2020

Highly homogeneous low-dose (50 µg) tablets were produced incorporating perfectly free-flowing granules prepared by a fully integrated Continuous Manufacturing (CM)...

Experimental setup for the continuous blending and tableting of the CFC-filtered ASA

Development of integrated continuous pharmaceutical technologies

9. December 2020

Thesis findings 1. Acetylsalicylic acid (ASA) was synthesized in continuous flow reactors for the first time. Design of experiment studies...

Directly compressible hydroxypropyl methylcellulose (HPMC) to support continuous manufacturing

5. December 2020

This work was undertaken to evaluate a novel hydroxypropyl methylcellulose excipient used in the manufacture of hydrophilic matrix tablets for...

Process Design of Continuous Powder Blending Using Residence Time Distribution and Feeding Models

24. November 2020

The present paper reports a thorough continuous powder blending process design of acetylsalicylic acid (ASA) and microcrystalline cellulose (MCC) based...

Towards better understanding of the influence of process parameters in roll compaction/ dry granulation on throughput, ribbon microhardness and granule failure load

16. November 2020

A key quality attribute for solid oral dosage forms is their hardness and ability to withstand breaking or grinding. If...

Residence time distribution modelling and in line monitoring of drug concentration in a tablet press feed frame containing dead zones

11. November 2020

The presence of a ‘significant dead zone’ in any continuous manufacturing equipment may affect the product quality and need to...

Continuous manufacturing