Continuous manufacturing

Highly homogeneous low-dose (50 µg) tablets were produced incorporating perfectly free-flowing granules prepared by a fully integrated Continuous Manufacturing (CM)...

Thesis findings 1. Acetylsalicylic acid (ASA) was synthesized in continuous flow reactors for the first time. Design of experiment studies...

This work was undertaken to evaluate a novel hydroxypropyl methylcellulose excipient used in the manufacture of hydrophilic matrix tablets for...

The present paper reports a thorough continuous powder blending process design of acetylsalicylic acid (ASA) and microcrystalline cellulose (MCC) based...

A key quality attribute for solid oral dosage forms is their hardness and ability to withstand breaking or grinding. If...

The presence of a ‘significant dead zone’ in any continuous manufacturing equipment may affect the product quality and need to...

Knowledge of residence time is a critical aspect in developing control and material diversion strategies for continuous manufacturing processes in...

Powder feeding is a crucial unit operation in continuous manufacturing (CM) of pharmaceutical products. Twin–screw feeders are typically employed to...

Continuous feeding of small quantities of powder is increasingly applied in pharmaceutical manufacturing. With that regard, what is crucial is...

A new approach is proposed to support prediction of tablet tensile strength as a function of both solid fraction (and/or...