Converting a batch based high-shear granulation process to a continuous dry granulation process

31. May 2020

When one wishes to convert a batch based manufacturing process of an existing tablet product to a continuous process, there...

In-line temperature measurement to improve the understanding of the wetting phase in twin-screw wet granulation and its use in process development

29. May 2020

Wetting is the initial stage of wet granulation processes during which the first contact between the powder and the liquid...

Schematic overview of the difference between material addition (batch) and feeding:dosing (continuous)

Feeding of particle-based materials in continuous solid dosage manufacturing: a material science perspective

5. May 2020

The pharmaceutical industry today is experiencing a paradigm shift from batch to continuous manufacturing, which promises greater flexibility to target...

Schematic presentation of the Eyecon® equipment working principle

Process analytical technology tools for process control of roller compaction in solid pharmaceuticals manufacturing

4. May 2020

Powders are often granulated to improve their flow properties, content uniformity and processability. Dry granulation is increasingly becoming a preferred...

$Scheme of a RCDG, in-and on-line laser diffraction$

Development and Evaluation of an In-line and On-line Monitoring System for Granule Size Distributions in Continuous Roll Compaction/Dry Granulation Based on Laser Diffraction

1. May 2020

Roll compaction/dry granulation is established in manufacturing of solid oral dosage forms and, within the context of continuous manufacturing, it...

Delta-mannitol to enable continuous twin-screw granulation of a highly dosed, poorly compactable formulation

29. April 2020

In current study, it was investigated if the moisture-mediated polymorphic transition from δ- to β-mannitol during twin screw granulation (TSG)...

Pharmacological treatment of hyperglycemia according to site of action

The manufacture of fixed dose combination products using advanced pharmaceutical techniques for the treatment of cardiovascular disease and type II diabetes

21. April 2020

Thesis by Jeremiah Kelleher, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, The University of Dublin The thesis has focused on...

End-to-End Continuous Manufacturing of Conventional Compressed Tablets: From Flow Synthesis to Tableting through Integrated Crystallization and Filtration

6. April 2020

An end-to-end continuous pharmaceutical manufacturing process was developed for the production of conventional direct compressed tablets on a proof-of-concept level...

INFLUENCE OF BINDER ATTRIBUTES ON BINDER EFFECTIVENESS IN A CONTINUOUS TWIN SCREW WET GRANULATION PROCESS VIA WET AND DRY BINDER ADDITION – Poster 2nd APV Continuous Manufacturing Conference

22. February 2020

As a switch to continuous twin screw granulation is quickly gaining momentum, the suitability of binders needs to be evaluated...

Benefits of Co-processed High-Functionality Excipients in a Continuous Direct Compression Process – 2nd APV Continuous Manufacturing Conference

21. February 2020

Continuous manufacturing offers significant advantages over conventional batch processing such as smaller equipment, less footprint and no need for upscaling...

Continuous manufacturing