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The best two choices for orally disintegrating tablets

In pharmaceutical business fields, patient-centric formulation is one of the areas Daicel focuses on and we have been developing new excipients using our technologies. Here we offer the best two choices for orally disintegrating tablets (ODTs).

Daicel orally disintegrating tablets

Product Information

HiSORADTM: New Directly compressible excipient for ODTs

Hisorad new generation

Product Features

  • HiSORAD is a state-of-the-art co-processed excipient for ODTs designed to have well-balanced property between oral disintegration time and tablet hardness.
  • HiSORAD realizes high tablet hardness possible even at relatively low compression forces. Tableting of poorly compressible APIs may be possible due to its excellent compactibility.
  • Ingredients: three compendial grade excipients: Mannitol, Microcrystalline Cellulose and Croscarmellose sodium.
  • Regulatory status: DMF under preparation

Characteristics

  • Excellent compactibility
  • Well-balanced tablet property between OD time and hardness
  • High API loading capacity
  • Simple composition

Tablet properties (Placebo)

  • High tablet hardness possible even at relatively low compression forces
  • Placebo tablet with HiSORAD draws water rapidly and disintegrates within 20 seconds.

compactibility

Disintegratability

Composition: HSR-D03 (99.5%) + Ca Stearate (0.5%)

Tableting Condition: Rotary-press, 20 rpm, Open-Feeder

Hardness: Measured by electronic hardness tester (Ave. of n=10)

Friability: Measured by JP general test method

Tablet Shape: 200 mg, φ8 mm, Flat-bevelled edge

Disintegration Time: Measured by JP general test method (D.T.) (Ave. of n=6)

Oral Disintegration Time: Measured by Tricorptester (Ave. of n=6)

(O.D.T) (Okada Seiko Co., Ltd. Tokyo, Japan)

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GRANFILLER-DTM: Directly compressible excipient for ODTs

GRANFILLER-DProduct Features

  • GRANFILLER-D is a co-processed excipient intended for preparing Orally Disintegrating Tablets (ODTs). It is designed to achieve rapid disintegration while maintaining high tablet hardness.
  • Ingredients: four compendial grade excipients: Mannitol, Microcrystalline Cellulose, Carmellose and Crospovidone.
  • Regulatory status: Listed in JPE2018, US-DMF and China-DMF filed.

Characteristics

  • Well-balanced tablet property between OD time and hardness
  • High API loading capacity
  • Excellent content uniformity
  • Compatible with various excipients

 

Application Examples Granfiller-d

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Contact

Mail Daicel

Daicel Excipients
Pharma Solutions
New Business Development
DAICEL CORPORATION
1-8-23, Konan, Minato-ku, Tokyo, 108-0075, Japan

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