Daicel

Daicel

The best two choices for orally disintegrating tablets

In pharmaceutical business fields, patient-centric formulation is one of the areas Daicel focuses on and we have been developing new excipients using our technologies. Here we offer the best two choices for orally disintegrating tablets (ODTs).

Daicel orally disintegrating tablets

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Product Information

HiSORAD^TM: New Directly compressible excipient for ODTs

Hisorad new generation

Product Features

HiSORAD is a state-of-the-art co-processed excipient for ODTs designed to have well-balanced property between oral disintegration time and tablet hardness.
HiSORAD realizes high tablet hardness possible even at relatively low compression forces. Tableting of poorly compressible APIs may be possible due to its excellent compactibility.
Ingredients: three compendial grade excipients: Mannitol, Microcrystalline Cellulose and Croscarmellose sodium.
Regulatory status: DMF under preparation

Characteristics

Excellent compactibility
Well-balanced tablet property between OD time and hardness
High API loading capacity
Simple composition

Tablet properties (Placebo)

High tablet hardness possible even at relatively low compression forces
Placebo tablet with HiSORAD draws water rapidly and disintegrates within 20 seconds.

compactibility

Disintegratability

Composition: HSR-D03 (99.5%) + Ca Stearate (0.5%)

Tableting Condition: Rotary-press, 20 rpm, Open-Feeder

Hardness: Measured by electronic hardness tester (Ave. of n＝10)

Friability: Measured by JP general test method

Tablet Shape: 200 mg, φ8 mm, Flat-bevelled edge

Disintegration Time: Measured by JP general test method (D.T.) (Ave. of n＝6）

Oral Disintegration Time: Measured by Tricorptester (Ave. of n=6)

(O.D.T) (Okada Seiko Co., Ltd. Tokyo, Japan)

DOWNLOAD BROCHURE OF HISORAD

GRANFILLER-D^TM: Directly compressible excipient for ODTs

Product Features

GRANFILLER-D is a co-processed excipient intended for preparing Orally Disintegrating Tablets (ODTs). It is designed to achieve rapid disintegration while maintaining high tablet hardness.
Ingredients: four compendial grade excipients: Mannitol, Microcrystalline Cellulose, Carmellose and Crospovidone.
Regulatory status: Listed in JPE2018, US-DMF and China-DMF filed.

Characteristics