How to Tame Recalcitrant Ingredients with Technological Processes

20. October 2021

Among the currently trending functional ingredients, interest in natural sources such as turmeric and its polyphenol, curcumin, has been increasing...

graphical abstract of Correlating Granule Surface Structure Morphology and Process Conditions in Fluidized Bed Layering Spray Granulation

Correlating Granule Surface Structure Morphology and Process Conditions in Fluidized Bed Layering Spray Granulation

15. October 2021

A workflow for developing a multidimensional, linear correlation between the process conditions during fluidized bed spray granulation and the surface...

Deformation potential and tensile strength of tablets of a dry granulated formulation

29. September 2021

The increase in solid fraction (SF) of a packed granule bed with pressure applied during the in-die compression process results...

Predicting the particle size distribution in twin screw granulation through acoustic emissions

17. September 2021

A non-destructive process analytical technology for monitoring the complex particle size distributions inherent to twin screw granulation (TSG) was presented,...

Figure 7 - Contour line plots of wet granulation cost when using stabilized (a) process parameters (torque) and (b) product quality (granule size) as the criterion to define the boundary of the start-up process.

Analysis of the Effects of Process Parameters on Start-Up Operation in Continuous Wet Granulation

8. September 2021

Toward further implementation of continuous tablet manufacturing, one key issue is the time needed for start-up operation because it could...

Figure 1. Typical pictures of heaps and of the flow inside the rotating drum with two powders (P2 and P4) and with granules G3

Flowing properties of spray-dried powders before and after granulation

6. September 2021

Abstract We study the flowing properties, the density and the packing dynamics of spray-dried powders produced with different nozzels and...

The PC1 vs PC2 score scatter plot. The color of the dots indicates different data sets where the green and red represent single materials and formulation mixtures respectively. The shape varies to discriminate where the data comes from: square means data extracted from iTCM database, circle represent data collected from literature respectively.

Using a material database and data fusion method to accelerate the process model development of high shear wet granulation

19. August 2021

High shear wet granulation (HSWG) has been wildly used in manufacturing of oral solid dosage (OSD) forms, and process modeling...

Granulation