Hot-melt extrusion

Abstract Solid dispersion (SD) system has been used as an effective formulation strategy to increase in vitro and in vivo performances of poorly water-soluble...

This article shows the content of a poster which was presented at the 𝗘𝗨𝗣𝗳𝗜 𝗰𝗼𝗻𝗳𝗲𝗿𝗲𝗻𝗰𝗲 𝗶𝗻 𝗚𝗹𝗮𝘀𝗴𝗼𝘄 2023 Introduction BCS...

Abstract Three different types of solid dispersions based on polyvinyl polymers and related copolymers (Kollidon® VA64, Soluplus® and Kollicoat IR®) comprising polydatin-rich Polygoni...

Hydrochlorothiazide (HTZ) is a potent thiazide diuretic that is used in the management of hypertension. However, HTZ suffers from low...

Conventional cyclodextrin complexation enhances the solubility of poorly soluble drugs but is solvent-intensive and environmentally unfavorable. This study evaluated solvent-free...

Ibrutinib (IBR) is a biopharmaceutical classification system (BCS) class II drug and an irreversible Bruton’s tyrosine kinase (BTK) inhibitor. IBR...

Background and purpose: Physicochemical properties of an amorphous solid dispersion (ASD) comprising an experimental grade of hydroxypropyl methylcellulose acetate succinate...

Abstract Purpose The present work was intended to develop the ibuprofen-Kollicoat® MAE 100P delayed-release pellets using hot-melt extrusion technology, which exhibits...

Abstract Lipid excipients are favorable materials in pharmaceutical formulations owing to their natural, biodegradable, low-toxic and solubility/permeability enhancing properties. The...

This study sought to develop polymer-lipid hybrid solid dispersions containing the poorly soluble drug lopinavir (LPV) by hot-melt extrusion (HME)....