Downstream processing of amorphous solid dispersions into tablets

19. February 2023

Amorphous solid dispersions have gained tremendous attention as a commercially viable solubility enhancement technique for poorly water-soluble drugs. However, poor...

Enhancing the oral drug delivery through hot melt extrusion techniques

17. February 2023

Hot melt extrusion has been developed as a fresh technique for taste masking, in recent years. This method provides many...

Hybrid Manufacturing of Oral Solid Dosage Forms via Overprinting of Injection-Molded Tablet Substrates

11. February 2023

Since 3D printing allows for patient-specific dosage forms, it has become a major focus in pharmaceutical research. However, it is...

Influence of PLGA End Groups on the Release Profile of Dexamethasone from Ocular Implants

7. February 2023

The present study deals with the development of dexamethasone (DM)-loaded implants using ester end-capped Resomer RG 502 poly(lactic acid-co-glycolic acid)...

The applications of machine learning to predict the forming of chemically stable amorphous solid dispersions prepared by hot-melt extrusion

31. January 2023

Amorphous solid dispersion (ASD) is one of the most important strategies to improve the solubility and dissolution rate of poorly...

Development of multifunctional drug delivery system via hot-melt extrusion paired with fused deposition modeling 3D printing techniques

20. January 2023

The model of core–shell structured tablets is gaining increased interest due to its advantages in controlled-release and combinational drug delivery....

Extrusion for pharma applications: An update

18. January 2023

This paper aims to give an overview of our current research and development on hot-melt extrusion (HME) for pharmaceutical formulation...

Drop-on-powder 3D printing of amorphous high dose oral dosage forms: Process development, opportunities and printing limitations

15. January 2023

Drop-on-powder 3D printing is able to produce highly drug loaded solid oral dosage forms. However, this technique is mainly limited...

Advances in Formulation and Manufacturing Strategies for the Delivery of Therapeutic Proteins and Peptides in Orally Disintegrating Dosage Forms

12. January 2023

Therapeutic proteins and peptides (TPPs) are increasingly favoured above small drug molecules due to their high specificity to the site...

Improving drug release rate, drug-polymer miscibility, printability and processability of FDM 3D-printed tablets by weak acid-base interaction

10. January 2023

Slow drug release, low drug-polymer miscibility, poor printability of polymers used, and high processing temperature are major challenges in developing...

Hot-melt extrusion