Hot-melt extrusion

Crystallinity in an amorphous solid dispersion (ASD) may negatively impact dissolution performance by causing lost solubility advantage and/or seeding crystal...

Hot-melt extrusion (HME) has emerged as a pioneering manufacturing technology for pharmaceutical industries, and the utilization is overgrowing due to...

While hot melt extrusion was developed in the 1930s and initially used in the plastics and food sector, the pharmaceutical...

In twin screw melt granulation, granules are produced by passing mixtures of drug substances and polymeric binders through twin screw...

Kollicoat® Smartseal (Methyl methacrylate and diethylaminoethyl methacrylate copolymer dispersion) which is used for taste masking and moisture protection, has shown...

Vitamin B12 deficiency is associated with high risks of cognitive decline, neuropathy, megaloblastic anaemia and depression. Therefore, there is a...

Interest in 3D printing for pharmaceutical applications has increased in recent years. Compared to other 3D printing techniques, hot melt...

Some of the major issues with the development of FDM 3D printed tablets are slow drug release, lack of drug-polymer miscibility,...

Rivaroxaban (RXB), a novel oral anticoagulant that directly inhibits factor Xa, is a poorly soluble drug belonging to Biopharmaceutics Classification...

Formulation development of amorphous solid dispersions (ASD) still is challenging although several poorly water-soluble drugs have been marketed using this...