Thermal Processing of PVP- and HPMC-Based Amorphous Solid Dispersions

1. January 2017

Abstract Thermal processing technologies continue to gain interest in pharmaceutical manufacturing. However, the types and grades of polymers that can...

Bioavailability enhancement of itraconazole-based solid dispersions produced by hot melt extrusion in the framework of the Three Rs rule

15. December 2016

15. December 2016 Abstract Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft...

Continuous Production of Itraconazole-based Solid Dispersions by Hot Melt Extrusion: Preformulation, Optimization and Design Space Determination

11. October 2016

The purpose of this work was to increase the solubility and the dissolution rate of itraconazole, which was chosen as...

PEO Hot Melt Extrudates for Controlled Drug Delivery: Importance of the Molecular Weight

26. September 2016

26. September 2016 Abstract Poly(ethylene oxide) (PEO)-based hot melt extrudates offer an interesting potential as oral controlled drug delivery systems...

Injection Molding as a One-Step Process for the Direct Production of Pharmaceutical Dosage Forms from Primary Powders

26. March 2016

26. March 2016 The objective of the present study was to develop a one-step process for the production of tablets...

Modifying release characteristics from 3D printed drug-eluting products

20. March 2016

20. March 2016 This work describes an approach to modify the release of active compound from a 3D printed model...

Comparison of metoprolol tartrate multiple-unit lipid matrix systems produced by different technologies

18. March 2016

The aim of this study was to develop, evaluate and compare extended release mini-matrices based on metoprolol tartrate (MPT) and...

Novel Controlled Release Polymer-Lipid Formulations Processed by Hot Melt Extrusion

9. January 2016

The aim of the study was to investigate the effect of novel polymer/lipid formulations on the dissolution rates of the...

TASTE-MASKING – Pharmaceutical Taste-Masking Technologies

20. November 2015

Taste-masking techniques are applied to mask or overcome the bitter or unpleasant taste of active pharmaceutical ingredients/drugs to achieve patient...

Application of Hot Melt Extrusion Technology in Drug Product Development

26. May 2015

26. May 2015 Application of Hot Melt Extrusion Technology in Drug Product Development - 8th Annual Charles I. Jarowski Symposium...

Hot-melt extrusion