Hot-melt extrusion

Thesis by Jeremiah Kelleher, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, The University of Dublin The thesis has focused on...

Multiple carriers may be used to prepare solid dispersions (SDs) for different purposes. The aim of this work is to...

The current study investigates the development of extemporaneous preparation of hot melt extruded diclofenac sodium (Df-Na) pellets processed with glyceryl...

A key principle of developing a new medicine is that quality should be built in, with a thorough understanding of...

One of the applications of Hot-Melt Extrusion (HME) is the stabilization of amorphous drugs through its incorporation into polymeric blends...

More than half of New Chemical Entities (NCEs), which were developed recently, tend to show high crystallinity and poor solubility in...

Hot-melt extrusion (HME) is increasingly applied in the pharmaceutical industry for the formulation of solid dispersions of drugs with improved...

Drug solubility is a persistent challenge in pharmaceutical product development. The objective of this research is to develop a formulation/processing...

The current study explored the twin-screw melt granulation (TSMG) as a potential technology for the water solubility enhancement of BCS...

Pharmaceutical research, whether industrial or academic, has attempted to adopt approaches most efficient for the development of innovations. With the...