Hot-melt extrusion

Controlled delivery systems are used to improve therapeutic efficacy and safety of drugs by delivering them at a rate dictated...

This study focuses on the impact of initial particle size on the tabletability and the deformation behaviour (i.e. plasticity) of...

The extensive use of oral dosage forms for the treatment of diseases may be linked to deficient pharmacokinetic properties. In...

To avoid any type of cross-contamination, residue-free production equipment is of utmost importance in the pharmaceutical industry. The equipment cleaning...

This paper presents a rational workflow for developing enabling formulations, such as amorphous solid dispersions, via hot-melt extrusion in less...

Amorphous solid dispersion (ASD) is a formulation strategy extensively used to enhance the bioavailability of poorly water soluble drugs. Despite...

AFFINISOL™ hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement by maintaining stable solid dispersions...

Many new chemical entities that are getting developed are poorly aqueous soluble and have low bioavailability. Out of many methods...

This study evaluates the potential use of zein as an excipient in hot-melt extrusion for controlled delivery of diclofenac sodium...

Hot melt extrusion is a promising technology for producing amorphous solid dispersions, however, there is a risk of thermal degradation...