The Novel Use of PVP K30 as Templating Agent in Production of Porous Lactose

It is necessary to prepare porous lactose in order to improve the dissolution behavior of insoluble active ingredient. In this study, polyvinylpyrrolidone K30 (PVP K30) was firstly utilized as a templating agent with different use levels in preparing porous lactose. Then, the physical properties were profoundly characterized. Finally, the porous lactose was also employed as a health functional food/drug carrier to explore the effect on the dissolution behavior of curcumin. The results confirmed that (i) porous lactose was successfully prepared using PVP K30 as templating agent; (ii) PVP K30 significantly improved the yield of lactose in the spray drying; (iii) the improved powder properties of porous lactose were more conducive to the downstream operating process for the preparation of health functional food or drug; and (iv) the porous lactose significantly improved the dissolution behavior of curcumin. Therefore, the results obtained are beneficial to boosting the development of porous materials

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or continue reading here: Zhu, W.-F.; Zhu, L.; Li, Z.; Wu, W.-T.; Guan, Y.-M.; Chen, L.-H.; Mao, Z.-X.; Ming, L.-S. The Novel Use of PVP K30 as Templating Agent in Production of Porous Lactose. Pharmaceutics 2021, 13, 814. https://doi.org/10.3390/pharmaceutics13060814

Materials
PVP K30 (Ashland, Wilmington, DE, USA), lactose (MEGGLE Excipients & Technology Group, Wasserburg am inn, Germany), and curcumin (Xi’an Hao-Xuan Bio-Tech Co., Ltd., Xi’an, China).

Conclusions
As is known to all, lactose is the most common excipient in health functional food and pharmaceutical industry, and it is needed to prepare porous lactose in order to increase the loading capacity and improve the dissolution behavior of insoluble active ingredients. Nowadays, the co-spray drying assisted with templating agent is the most popular method for the production of porous material.
In this study, PVP K30 was firstly utilized as templating agent with different use level to prepare porous lactose. Then, the surface morphology, surface area, pore volumes, pore diameter, powder properties, X-ray diffraction, Fourier transform infrared spectrometer, thermal gravity, and differential thermal gravity were profoundly characterized. Finally, the porous lactose was also employed as a health functional food carrier to explore the effect on the dissolution behavior of curcumin. The results demonstrated that (i) porous lactose was successfully prepared using PVP K30 as templating agent; (ii) PVP K30 significantly improved the yield of lactose in the spray-drying; (iii) the improved powder properties of porous lactose were more conducive to the downstream operating process for the preparation of health functional foods/drugs; and (iv) the porous lactose significantly improved the dissolution behavior of curcumin.
The results obtained could provide new perspectives, theoretical support, and guidance on the development of porous materials. Therefore, this study might be significant in facilitating the development of health functional food.