Studies on enhancement of solubility and dissolution properties of Nimodipine by solid dispersion technique

Nimodipine, a member of calcium channel blocker, specifically binds to L-type voltage-gated calcium channels. The maximum solubility of nimodipine was found at pH 1.2 and solubility decreases up to pH 4.0. At a pH 6.0 and higher pH, solubility reduces drastically. Suitable solid dispersion systems of nimodipine with PVP-K30 and maltodextrin were prepared by physical mixture, solvent evaporation and kneading methods at 1:1 and 1:3 drug: carrier. Drug content, saturation solubility, FTIR, and in-vitro dissolution were studied.

The drug content was uniform, solubility of the drug increased linearly as a function of the carrier concentration and method. The FTIR studies indicates no chemical interaction between drug and polymer. The DP₆₀ and DE₆₀ values of solid dispersion systems prepared by solvent evaporation and kneading method were significantly higher (P<0.05) when compared to DP₆₀ and DE₆₀ values of physical mixture and pure Nimodipine. The dissolution follows first order model and obeyed Hixson- Crowell’s cube root law.

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Materials

The drug Nimodipine was obtained as a gift sample from AET Pharmaceuticals, Hyderabad. Maltodextrin was procured from Sigma Aldrich. PVP K-30, Methanol, Hydrochloric acid, Ethanol and Dichloromethane were obtained from sd finechem. Limited, Mumbai.

Srivatsa Sangwar, Sakshi R, Balaram Vaishnapu, Anand Kumar Y and Murthy PNVN, Studies on enhancement of solubility and dissolution properties of Nimodipine by solid dispersion technique, Magna Scientia Advanced Research and Reviews, 2024, 11(01), 010–018​, Article DOI: 10.30574/msarr.2024.11.1.0068, DOI url: https://doi.org/10.30574/msarr.2024.11.1.0068, Received on 08 March 2024; revised on 27 April 2024; accepted on 29 April 2024

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