Impact of co-processed excipient particles solidity and circularity on critical quality attributes of orodispersible minitablets

6. April 2021

The selection of appropriate functional co-processed excipient (CPE) is a crucial stage in orodispersible minitablets (ODMTs) development. This paper aimed...

Rapid prototyping of miniaturized powder mixing geometries

3. April 2021

Continuous manufacturing is an important element of future manufacturing solutions enabling for both high product quality and streamlined development process....

Performance Evaluation of a Novel Biosourced Co-Processed Excipient in Direct Compression and Drug Release

29. March 2021

This study exposes the potential usefulness of a new co-processed excipient, composed of alginic acid and microcrystalline cellulose (Cop AA-MCC),...

graphical abstract of Influence of high pressure compaction on solubility and intrinsic dissolution of ibuprofen binary mixtures employing standard excipients

Influence of high pressure compaction on solubility and intrinsic dissolution of ibuprofen binary mixtures employing standard excipients

24. March 2021

Enabling formulations often depend on functional excipients. However, the question remains whether excipients regarded as standard establish similar interactions and...

Tablet disintegration performance: effect of compression pressure and storage conditions on surface liquid absorption and swelling kinetics

24. March 2021

The disintegration process of pharmaceutical tablets is a crucial step in the oral delivery of a drug. Tablet disintegration does...

Quality by Design Applied Development of Immediate-Release Rabeprazole Sodium Dry-Coated Tablet

21. February 2021

The aim of this study was to develop immediate-release oral rabeprazole sodium tablets with rapid efficacy and gastric stability for...

3D printer with modified printhead for 3D printing of rigid filaments and schematic drawing of the pressure sensitive capsule

In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for Oral Peptide Delivery

19. February 2021

In this study a 3D printed capsule designed to break from the physiological pressures in the antropyloric region was evaluated...

Generation of Ophthalmic Nanosuspension of Prednisolone Acetate Using a Novel Technology

14. February 2021

Purpose Prednisolone Acetate (PAC) is currently marketed as micronized ophthalmic suspension. The microsuspension has poor dose accuracy and efficacy due...

Concise overview of the critical binder attributes influencing the binder effectiveness for a poorly and highly soluble formulation

Identifying Critical Binder Attributes to Facilitate Binder Selection for Efficient Formulation Development in a Continuous Twin Screw Wet Granulation Process

9. February 2021

The suitability of pharmaceutical binders for continuous twin-screw wet granulation was investigated as the pharmaceutical industry is undergoing a switch...

Unit operations employed in the production of tablets via granulation or spray:co-spray drying

Spray Drying for Direct Compression of Pharmaceuticals

8. February 2021

Tableting by direct compression (DC) is one of the simplest and most cost-effective drug manufacturing approaches. However, most active pharmaceutical...

Mannitol