Cellulose and its derivatives for application in 3D printing of pharmaceuticals

Background

Three-dimensional printing (3DP) has emerged as an advanced manufacturing technology capable of producing complex yet precise medicines intended for patient-centric drug therapy. However, printable materials currently available for 3DP are far too limited.

Area covered

The current article covers various cellulose-based polymers as well as their applications, especially in 3DP of oral solid dosage forms. The review focuses on their physicochemical properties, roles, and functions in conventional as well as 3DP dosage forms, and the characteristics of the obtained printed products are discussed. In addition, the challenges and considerations for processing cellulose-based feedstock materials are briefly presented.

Expert opinion

Evaluation of 3D-Printed Solid Microneedles Coated with Electrosprayed Polymeric Nanoparticles for Simultaneous Delivery of Rivastigmine and N-Acetyl Cysteine

Innovative pharmaceutical techniques for Paediatric dosage forms: a systematic review on 3D printing, prilling/vibration and microfluidic platform

Progress and Opportunities for Machine Learning in Materials and Processes of Additive Manufacturing

Cellulose and its derivatives are regarded as suitable polymers with a huge potential for applications in 3DP drug delivery systems. It is therefore essential to better understand cellulose-based printable polymers and their applications in 3DP.

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Giri, B.R., Poudel, S. & Kim, D.W. Cellulose and its derivatives for application in 3D printing of pharmaceuticals. J. Pharm. Investig. (2020). https://doi.org/10.1007/s40005-020-00498-5
https://doi.org/10.1007/s40005-020-00498-5

Keywords:Cellulose, 3D printing, Hydroxypropyl methylcellulose, Hydroxypropyl cellulose, Ethylcellulose, Hydroxypropyl methylcellulose acetate succinate

excipients formulation