Comilling of telmisartan with poly(vinyl alcohol) – An alkalanizer free green approach to ensure its bioavailability
The aim of this study was to enhance the dissolution and bioavailability of telmisartan (TLM), a poorly water soluble drug by comilling approach. Physical mixtures of TLM and poly(vinyl alcohol) (PVA) were comilled in a planetary micro mill in a dry condition by varying process parameters such as drug to polymer weight ratio, ball-to-powder weight ratio, and rotational speed. The comilled products that offered cumulative percentage dissolution of TLM above 75% in 30 min (CG 1 and CG2). These samples were characterized using field emission scanning electron microscopy (FE-SEM), powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC) and Raman spectra analysis.