Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines

12. July 2023

Ever since the development of the first vaccine, vaccination has had the great impact on global health, leading to the...

Neutralisation of SARS-CoV-2 by monoclonal antibody through dual targeting powder formulation

12. May 2023

Neutralising monoclonal antibody (mAb) is an important weapon in our arsenal for combating respiratory viral infections. However, the effectiveness of...

Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures

5. April 2023

Messenger RNA (mRNA) lipid nanoparticles (LNPs) have emerged at the forefront during the COVID-19 vaccination campaign. Despite their tremendous success,...

The Role of Cyclodextrins in COVID-19 Therapy—A Literature Review

24. February 2023

Coronavirus disease-19 (COVID-19) emerged in December 2019 and quickly spread, giving rise to a pandemic crisis. Therefore, it triggered tireless...

Iterative Design of Ionizable Lipids for Intramuscular mRNA Delivery

24. January 2023

Lipid nanoparticles (LNPs) are the most clinically advanced delivery vehicles for RNA and have enabled the development of RNA-based drugs...

SARS-CoV-2 vaccine excipients polyethylene glycol and trometamol do not induce mast cell degranulation, in an in vitro model for non-IgE-mediated hypersensitivity

22. January 2023

The development of vaccines against SARS-CoV2 brought about several challenges, including the management of hypersensitivity reactions to these formulations. The...

Microcrystalline cellulose promotes superior direct compressed Boesenbergia rotunda (L.) Mansf. extract tablet properties to spray-dried rice starch and spray-dried lactose

16. December 2022

This work aimed to select tablet diluent of Boesenbergia rotunda (L.) Mansf. extract tablet. Three tablet diluents, including microcrystalline cellulose (MCC), spray-dried...

Assessing the Solubility of Baricitinib and Drug Uptake in Different Tissues Using Absorption and Fluorescence Spectroscopies

9. December 2022

The low water solubility of baricitinib (BCT) limits the development of new formulations for the topical delivery of the drug....

Novel trehalose-based excipients for stabilizing nebulized anti-SARS-CoV-2 antibody

6. December 2022

COVID-19 is caused by the infection of the lungs by SARS-CoV-2. Monoclonal antibodies, such as sotrovimab, showed great efficiency in...

Effect of binder type on physical and in vitro properties of high dose inosine acedoben dimepranol tablets

24. October 2022

The present work was conducted with the aim to formulate and evaluate the immediate release of 1000 mg tablets containing...

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