Modeling of inter-tablet coating uniformity of electrostatic dry powder coating by discrete element method
The current study aims to apply an innovative mathematical model based on the discrete element method to numerically simulate the electrostatic dry powder coating process and to predict the inter-tablet coating uniformity. The newly developed mathematical model could efficiently handle millions of coating particles and precisely obtain the coating weight gain of individual tablet core online, which was highly consistent with the experimental results.
Highlights
A novel DEM-based mathematical model for electrostatic dry powder coating
Validation of the newly developed model with optimized simulation settings
Precise prediction of the inter-tablet coating uniformity by modulating the coating parameters
And the newly developed model was applied to fully investigate the influence factors of the inter-tablet coating uniformity of electrostatic powder coating, including coating particle radius, charge intensity of the coating particles, the rotating speed of the pan coater and the feeding time of the coating powders, all of which could be optimized to largely improve the coating uniformity. The study demonstrates that this newly developed model is promising in precisely simulating the electrostatic dry powder coating process for sufficient coating uniformity.
Qingliang Yang, Jiale Chen, Xuhui Zhou, Hang Zhou, Gensheng Yang, Jesse Zhu, Modeling of inter-tablet coating uniformity of electrostatic dry powder coating by discrete element method, Powder Technology, Volume 411, 2022, 117929, ISSN 0032-5910, https://doi.org/10.1016/j.powtec.2022.117929