Processed excipients for targeted drug delivery in cancer management: Enhancing efficacy and precision

Processed excipients (PEs) function in creating various dosage forms and need no introduction. For instance, recent studies have shown that PEs oleic acid, which is used with the breast cancer medicine Herceptin, functions both as a liquid delivery system for drugs and has the ability to suppress the breast cancer gene. Gamma-linolenic acid and omega-3 fatty acids, respectively, have some positive impacts on anticancer activity and cardiovascular advantages. PEs can transport other medications in liquid form, but they can also destabilise APIs. The physical interactions between excipients can alter how quickly a solid dosage form dissolves.

The aim of the study is to investigate the crucial role of processed excipients (PEs) in creating diverse dosage forms, with a particular focus on their functions, effects, and interactions. The study also aims to explore recent research findings that demonstrate the potential of certain PEs, such as oleic acid, gamma-linolenic acid, and omega-3 fatty acids, in drug delivery and their potential therapeutic impact, including suppressing breast cancer genes and enhancing anticancer and cardiovascular activities. Furthermore, the study aims to delve into the dual nature of PEs, where they can both facilitate the delivery of drugs in liquid form and potentially influence the stability and dissolution characteristics of active pharmaceutical ingredients (APIs). It seeks to examine the intricate interplay between different excipients and their effects on drug bioavailability and functionality.

The study acknowledges the global health burden posed by cancer and aims to highlight the application of traditional and emerging therapies, such as phytochemicals, in cancer treatment. It also intends to discuss the challenges associated with conventional chemotherapy, including the development of drug resistance. Additionally, the study aims to emphasise the continued relevance of PEs in the formulation of biologic medicinal products, particularly in the context of injection-based delivery methods. It aims to address the crucial considerations surrounding endotoxins and microbiological quality in these products. Overall, the study aims to contribute to a deeper understanding of the multifaceted roles and significance of PEs in pharmaceutical formulation and their impact on drug delivery, stability, and therapeutic outcomes.

^{Table 1. Types of PEs used in the formulation of lipid based carrier system.50}

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Following excipients are mentioned in the study besides other: PROSOLV® EASYtab SP

Aditya Singh, Shubhrat Maheshwari, Vishal Kumar Vishwakarma, Saad Mohammed, Processed excipients for targeted drug delivery in cancer management: Enhancing efficacy and precision, Intelligent Pharmacy, 2023, ISSN 2949-866X, https://doi.org/10.1016/j.ipha.2023.10.006.

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