“Green” technology of centrifugal fiber formation of solid dispersed systems of nimesulide: Evaluation of solubility increases and physicochemical characteristics

Abstract

This work reports on the first developed solid dispersed systems (SDSs) of nimesulide using technology of centrifugal fiber formation, which meets the principles of “green chemistry” and provides increased solubility of the active pharmaceutical ingredient (API).

Highlights

• Solid dispersed systems (SDS) of nimesulide can be formed by “green” technology of centrifugal fibre formation.
• SDS of nimesulide in fibre form can be obtained using a cotton candy machine.
• The solubility of nimesulide is improved in centrifugally formed SDS.
• Nimesulide is amorphized in SDS with the formation of hydrogen bonds.

Polyvinylpyrrolidone (PVP) with different molecular weights, sucrose, and mannitol were used to form SDSs fibers. A comparative analysis of 22 samples of SDS of nimesulide different compositions was carried out and the 4 best samples were selected, which were characterized by a high fiber yield (>70%) and good indicators of improving the solubility of nimesulide in water (more than 3–5 times).

The study of changes in the physicochemical properties of nimesulide as part of SDSs was carried out using the methods of differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy and powder X-ray diffraction (PXRD). All these methods confirm that nimesulide in SDSs is molecularly dispersed in the carriers matrix and is in an amorphous state, and the interaction between the components of the systems probably occurs as a result of the formation of intermolecular hydrogen bonds.

In vitro kinetic studies confirmed that in the buffer media studied (pH 6.8, 7.5 and 7.8), the dissolution of nimesulide from centrifuged SDSs is faster and more complete than from the original drug Aulin granules. This study demonstrates for the first time the effectiveness of centrifugal fiber formation as an environmentally friendly and cost-effective technology for the production of SDSs of nimesulide, which improves API solubility while adhering to the principles of sustainable pharmaceutical production.

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Materials

Nimesulide was purchased from Mangalam Drugs and Organics Ltd. (India). Polyvinylpyrrolidone (PVP) K-12 with an average molecular weight of 2500 Da and PVP K-17 with an average molecular weight of 10,000 Da were purchased from JRS PHARMA GmbH & Co. KG (Germany). Mannitol, sucrose and all buffer salts used in the in vitro dissolution studies were purchased from Merck (Germany).

Volodymyr Bessarabov, Viktor Kostiuk, Viktoriia Lyzhniuk, Vadym Lisovyi, Roman Smishko, Galina Kuzmina, Svitlana Gureyeva, Andriy Goy, “Green” technology of centrifugal fiber formation of solid dispersed systems of nimesulide: Evaluation of solubility increases and physicochemical characteristics, Sustainable Chemistry and Pharmacy, Volume 43, 2025, 101913, ISSN 2352-5541, https://doi.org/10.1016/j.scp.2025.101913.

Read also our introduction article on Mannitol here: