Formulation and assessment of hydroxyzine HCL solid lipid nanoparticles by dual emulsification technique for transdermal delivery

Hydroxyzine HCL (HHCL) is an antihistamine, used for the treatment of allergic skin conditions. The purpose of this study was to achieve a dual phase drug delivery rate across the intact skin, to enhance HHCL permeation through the stratum corneum, to assess the peripheral H₁-antihistaminic activity and the extent to which HHCL was systemically absorbed from transdermal gel loaded with solid lipid nanoparticles (SLNs), as well as to avoid its extreme bitterness.

Highlights

HHCL is an antihistamine, used for the treatment of allergic skin conditions.

SLNs- HHCL transdermal gel can achieve a dual release effect.

An improved atopic dermatitis was achieved with no inflammatory cells infiltrating the dermis in rats.

SLNs can penetrate the deeper layers of the skin.

According to 2³ factorial design, eight formulations of HHCL-SLNs were prepared by the double emulsification method. Lipid type (X_A), surfactant concentration (X_B) and co-surfactant concentration (X_C) were the independent variables. All formulations were characterized for their surface morphology, particle size, entrapment efficiency and in-vitro drug release study. The optimized formula that provides greater desirability was then incorporated into the transdermal gel. In addition, the efficacy of the developed gel was tested in-vivo using 2,4-Dinitrochlorobenzene induced atopic dermatitis as lesion model in mice.

F4 showed an average diameter 111 nm ± 0.03, zeta potential − 30 MV ± 2.4 and EE 75.2% ± 4.4. TEM images showed spherical, smooth morphology with uniform particles distribution. In-vivo study demonstrated potent antipruritic efficacy of transdermal gel in atopic dermatitis such as induced lesions compared to HHCL gel. Hence, HHCL solid lipid nanoparticles transdermal gel may be considered as potential for delivery of HHCL and alternatively to traditional oral use.

Read the article here

Article information: Dalia Farag A. El-Telbany, Rania Farag A. El-Telbany, Sherin Zakaria, Kawkab A. Ahmed, Yasmin A. El-Feky, Formulation and assessment of hydroxyzine HCL solid lipid nanoparticles by dual emulsification technique for transdermal delivery, Biomedicine & Pharmacotherapy, Volume 143, 2021. https://doi.org/10.1016/j.biopha.2021.112130.