Evaluating the effect of glidants on tablet sticking propensity of ketoprofen using powder rheology

Punch sticking has been a leading drawback that has challenged successful tablet manufacturing since its initial conception. Due to the capricious nature of the complication, this can arise during any phase of the development process. Even now, identifying such a problem is a prerequisite during the initial stage of development. The present study evaluated the role of Aerosil®200, talc, and Syloid®244 as glidants in varying amounts ranging from 0.0 percent to 2.0 percent w/w on tablets sticking relatively to five different metal surfaces, with ketoprofen as the model drug. Powder rheology is a predictable technique used to calculate the sticking index.

Highlights

• Powder rheology is a potential tool to predict tablet sticking at an early stage.
• Tablet sticking is caused primarily by the formulation’s cohesive and adhesive properties.
• Selection of glidant must be made to avoid tablet sticking as not all glidants can aid to tablet sticking.
• The collective effect of glidant with certain metal surfaces can reduce tablet sticking.

The sticking index of each formulation in comparison to each metal coupon was identified by calculating the kinematic angle of internal friction and the angle of wall friction using the shear cell test and wall friction test, respectively. Interestingly, glidants were found to reduce the sticking propensity of the powder blend in a concentration-dependent manner. In addition, the compression study validated the expected sticking tendency ranking order. According to the research data, the sticking index could effectively be utilized to envisage the possibility of tablet sticking, i.e., by selecting the formulation’s excipient and their percentages or selecting appropriate punched metal surfaces in the tableting process.

Read more

Bhavin V. Parekh, Joseph S. Saddik, Devang B. Patel, Rutesh H. Dave, Evaluating the effect of glidants on tablet sticking propensity of ketoprofen using powder rheology, International Journal of Pharmaceutics, 2023, 122710, ISSN 0378-5173, https://doi.org/10.1016/j.ijpharm.2023.122710.