Novel Carrier Systems for Targeted and Controlled Drug Delivery

See the new book, edited by Awesh K. Yadav, Keerti Jain. Here the general concepts and new research results on targeted and controlled drug delivery are examined. Challenges and future directions in controlled drug delivery are discussed and the drug delivery system based on colloidal and polymeric nanoparticles is presented.

Description: The book presents novel carrier systems for the targeted and controlled drug delivery for the treatment of various diseases which are difficult to be treated with conventional drug delivery systems like cancer, autoimmune disorders, and emerging infectious diseases. It also reviews the origins and applications of stimuli-responsive polymer systems and polymer therapeutics such as polymer-protein and polymer-drug conjugates. The book also explores the potential applications of the parenteral route of administration for the delivery of active pharmaceutical substances with a narrow therapeutic index and poor bioavailability. Further, the book presents common routes of administration for the systemic delivery of peptides and proteins. It also examines the applications of various implantable systems in drug delivery. The book also covers the important colloidal drug delivery systems, including liposomes and niosomes and solid lipid nanoparticles, and nanostructured lipid carriers. Towards,the end, the book discusses the therapeutic potential of biodegradable polymeric nanoparticles for controlled drug delivery. Authoritative and thorough, this book is a valuable resource for researchers working on a multidisciplinary approach to employing drug delivery systems.

Chapter 1

Influence of Drug Properties and Routes of Drug Administration on Design of Sustained and Controlled Release Systems

To efficiently approach the site of action after administration, every therapeutic molecule requires a capable delivery system. In case of freshly developed new chemical entity for therapeutic purpose, the selection and development of suitable dosage form are very critical to get the maximal efficacy for the treatment of target disease. When we opt for traditional drug delivery systems, they generally offer instant release of incorporated drug without any control on the release rate. On the other hand, sustained release and controlled release delivery systems are out-and-out influential for their inimitable benefits, e.g., reduction in dosing frequency, superior bioavailability of incorporated therapeutics, extension of the duration of effective blood-plasma levels, minimal peak-to-trough concentration fluctuation, and reduced side effects associated with conventionally developed formulations.

See the chapter

Kumar, A., Jain, S.K., Mishra, D.K., Gautam, R. (2024). Influence of Drug Properties and Routes of Drug Administration on Design of Sustained and Controlled Release Systems. In: Yadav, A.K., Jain, K. (eds) Novel Carrier Systems for Targeted and Controlled Drug Delivery . Springer, Singapore. https://doi.org/10.1007/978-981-97-4970-6_1

Chapter 4

Parenteral Drug Delivery

Conventional and novel parenteral drug delivery systems play a pivotal role in enhancing the efficacy and bioavailability of pharmaceutical compounds. Conventional formulations like solutions, parenteral suspensions, emulsions, and microemulsions have been integral to delivering a wide range of therapeutics. However, the limitations of these systems, such as poor stability and solubility, have driven innovation towards novel alternatives. Novel parenteral drug delivery systems, including nanosuspensions, lipid-based carriers like nanostructured lipid carriers and solid lipid nanoparticles, liposomes, and micelles, have emerged as promising solutions. These systems offer benefits such as enhanced drug solubility, controlled release, and targeted drug delivery, overcoming challenges posed by conventional counterparts. By harnessing nanotechnology and lipid-based carriers, these novel approaches offer superior drug delivery options, ensuring better patient compliance and therapeutic outcomes. The continuous evolution of drug delivery techniques holds great promise for the pharmaceutical industry, with these innovations addressing the need for improved drug delivery efficiency and safety.

See the chapter

Alam, M.I., Yadav, A.K. (2024). Parenteral Drug Delivery. In: Yadav, A.K., Jain, K. (eds) Novel Carrier Systems for Targeted and Controlled Drug Delivery . Springer, Singapore. https://doi.org/10.1007/978-981-97-4970-6_4

Chapter 9

US FDA’s Regulatory Considerations and Framework for Approval of Controlled Release Delivery Systems

The prime intent of the current book chapter is to provide a holistic overview of United States Food and Drug Administration (USFDA’s) regulatory approval process for controlled release delivery systems while highlighting the critical aspects taken into the consideration. Administering the medication(s) at a well-controlled rate ensures the highest possible level of efficacy and safety. Consequently, drug delivery systems with regulated release patterns are being developed to optimize bio-pharmaceutics, pharmacokinetics, and pharmacodynamics properties of drugs. Thus, such systems being recognized as newer class of drugs follow different regulations for their approval into the market. Hence, it becomes quite appealing to know the aspects being considered for framing the regulations and pathways being followed for such approvals. In this chapter, we have provided a brief account on the controlled release delivery systems and their mechanisms of drug release followed by bird’s eye view of USFDA regulatory considerations and framework for their approval. The multitude of benefits offered by controlled delivery systems makes it essential to have stringent regulations for their approval. In this regard, there are rules in place, with different pathways available, by regulatory agencies, such as FDA for controlled release formulations. The safety and effectiveness of the pharmaceuticals rely heavily on the rigor of pharmaceutical regulations around the world. They control not only drug prices but also standards. Thus, the primary objective of the review is to conduct a thorough examination and furnish a discerning appraisal of the regulatory framework governing controlled release delivery systems, as presently embraced by the USFDA.

See the chapter

Sharma, S., Sharma, T., Jain, A. (2024). US FDA’s Regulatory Considerations and Framework for Approval of Controlled Release Delivery Systems. In: Yadav, A.K., Jain, K. (eds) Novel Carrier Systems for Targeted and Controlled Drug Delivery . Springer, Singapore. https://doi.org/10.1007/978-981-97-4970-6_9

Chapter 11

Fundamentals of Targeted Drug Delivery

The goal of targeted drug delivery systems (TDDS) is to identify the target and deliver the loaded bioactive into predefined target with minimum unhealthy side effects. Drug targeting makes it simpler for the medicinal agents to achieve the desired boy site and demonstrates an enhanced beneficial effect at a predefined rate and time. Additionally, it improved the pharmacological effect and reduced unpleasant taste of drug. The role of TDDS is to identify the drug part precisely into its affected body area to overcome a particularly lethal impact of traditional drug delivery, thus decreasing the quantity of drug needed for therapeutic effectiveness. The benefits of the TDDS are the decrease in the occurrence of the dosing, consistent drug effects, decrease of drug side effects, and minimization of the variation in distributing drug quantities. Various carrier systems include colloidal delivery systems, cellular systems, and polymeric systems. This chapter discusses the basic principles of TDDS, types of TDDS, commonly used drug delivery systems, and future prospects of TDDS.

See the chapter

Pandey, V., Haider, T., Sharma, R., Akram, W., Soni, M.L., Mishra, N. (2024). Fundamentals of Targeted Drug Delivery. In: Yadav, A.K., Jain, K. (eds) Novel Carrier Systems for Targeted and Controlled Drug Delivery . Springer, Singapore. https://doi.org/10.1007/978-981-97-4970-6_11

See the full book here

Awesh K. Yadav, Keerti Jain, Novel Carrier Systems for Targeted and Controlled Drug Delivery, 2024, Springer Singapore, https://doi.org/10.1007/978-981-97-4970-6