Insights in the rheological properties of PLGA-PEG-PLGA aqueous dispersions: structural properties and temperature-dependent behaviour

PLGA-PEG-PLGA are copolymers, able to form temperature-dependent hydrogels or sol dispersions at selective conditions. A general overview about the rheological characterization of their aqueous dispersions, focusing how the structural characteristics (e.g. molecular weight, PEG/PLGA ratio) affect their temperature-dependent behaviour, is presented. Different PLGA-PEG-PLGA were synthesized by varying the amount of lactide and glycolide and the amount and molecular weight of PEG. All polymers were characterised by gel-permeation chromatography and differential scanning calorimetry.

Highlights:

All PLGA-PEG-PLGA copolymers are amorphous; T_g values were dependent on the PEG/PLGA

Aqueous dispersions were categorised in terms of temperature-dependent behaviour

Partial thermogelling, thermogelling and sol rheological behaviours were described

In partially thermogels, consistency increases over temperature without a 3D network

Thermogels were observed for copolymers having a PEG/PLGA ratio around 0.45-0.5

Then, polymeric dispersions in water (15%-25% w/w) were analysed by oscillatory rheological measurements. At solid state, all copolymers are amorphous and the calculated glass transition temperatures were dependent on PEG/PLGA ratio. As regard aqueous dispersions, the temperature-dependent rheological behaviour named “partially thermogelling” has been described, in addition to the commonly reported thermogelling one. In these samples, the consistency increases over temperature without forming a three-dimensional network as for real hydrogels. All rheological characteristics can be explained according to the proposed categorization (thermogel, partial thermogel and sol dispersion).

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Article Information: Marco Cespi, Giulia Bonacucina, Mattia Tiboni, Luca Casettari, Alessandra Cambriani, Francesco Fini, Diego Romano Perinelli, Giovanni Filippo Palmieri. Insights in the rheological properties of PLGA-PEG-PLGA aqueous dispersions: structural properties and temperature-dependent behaviour, Polymer, 2020. https://doi.org/10.1016/j.polymer.2020.123216.