A technical note: Characterization and evaluation of novel, ready to use coprocessed excipient in nutraceutical herbal vitamin and amino acid formulations

Abstract

A tablet is composed of different excipients and drug. All excipients have different properties with applications. Excipients are used to provide bulk and help to bind API into a dosage form, excipient should be inert in nature with respectable physical properties. Because the physical properties play a very important role during tablet compaction. However, maximum individual excipients do not have enough physical properties especially flowability. To fulfil these requirements co-processed excipient have been starting to use in formulation industries to make tablet and capsules. All co-processes excipients have superior flowability and other physical properties and now co-processed excipients have made their own place in pharma industries. BARETab® Nutra is also a co-processed excipient, but it is a ready to use premix for direct compressible tablet and contains four different excipients like binder, glidant, disintegrant and lubricant .

This study is aimed at making herbal extracts, vitamins and non-essential amino acids tablet, using BARETab® Nutra by direct compression method and evaluate in-vitro parameters like hardness, friability, disintegration time and drug released profile. Ready to use premix BARETab® Nutra delivers good tableting parameters in herbal tablet Glucosamine, vitamin tablet Pyridoxine hydrochloride and non-essential amino acid Cysteine tablet like as higher tablet hardness, less friability, less disintegration time and uniform tablet weight. All tablets carried equal amount of drug which is proved by dissolution test.

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Material

BARETab® Nutra, filler, binder and disintegrant manufactured at Sigachi Industries Ltd. in Dahej, Gujarat. Glidant purchased form Nikon Corporation, Wacker Germany, lubricant purchased from Sun Shine private Limited, India, Glucosamine purchased from Herbo Nutra Delhi, India and Vitamin, and amino acids API’s are purchased and Chemzone pharma, Ahmedabad, Gujarat (India), others chemicals AR grade are used in this study.

Source: Sigachi, A technical note: Characterization and evaluation of novel, ready to use coprocessed excipient in nutraceutical herbal vitamin and amino acid formulations, Tomar Monika and Sinha Amit Raj, GSC Biological and Pharmaceutical Sciences, 2020, 11(02), 233–241, e-ISSN: 2581-3250, CODEN (USA): GBPSC2, Journal homepage: https://www.gsconlinepress.com/journals/gscbps, Article DOI: https://doi.org/10.30574/gscbps.2020.11.2.0142, Publication history: Received on 16 May 2020; revised on 21 May 2020; accepted on 24 May 2020

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