The aim of the present investigation was to understand the swelling behaviour of HPMC and PEO-based matrices and to evaluate the impact of porosity on the swelling kinetics. It was noticed that the HPMC has higher swelling rates but both undergo diffusion oriented swelling mechanism. It could also the concluded that the porosity has a marked influence in the development of gel layer on the surface of these matrices.

Conclusions

It can be concluded that the HPMC had a higher swelling rate in comparison to PEO, under the conditions in this study. Moreover, it could also the concluded that from the above research finding that the porosity has a marked influence on the overall swelling behaviour of the polymer matrices. Therefore, the present findings can be used in the development and tailoring the specific properties of controlled release solid dosage forms.