Orally disintegrating dosage forms
What is an orally disintegrating dosage form?
An orally disintegrating tablet is a novel formulation that dissolves in the saliva within a few seconds and without requiring of drinking additional water. This dosage form is a powerful way to deliver active drugs ingredients because it has many advantages. Many studies have compared this form of tablet with the ordinary forms in vitro and in vivo and found that orally disintegrating tablets have superior patient compliance and drug solubility. However, there are some criteria for the active pharmaceutical ingredients to prepare tablets as fast dissolve forms. There are several ways to prepare this dosage form and each method has its pros and cons. Technologies of preparation and various examples of orally disintegrating tablet available in the market using different preparing procedures are presented in this review. Taste masking is required form some active pharmaceutical ingredients to be formed as orally disintegrating tablets. In vitro evaluation and quality control measures of orally disintegrating tablet is also discussed in this review.
ODTs are fast dispersing tablets that are administered without the need for water. This dosage form is a modern way to deliver APIs. They might be used in cases, which required a fast onset of action or to overcome compromised ability to swallow tablets. ODTs have many advantages, and there are many ways to overcome some of their disadvantages such as taste masking of bitter drug substances. There are several different ways to prepare this kind of dosage form and there is no best or preferred method but each has its Advantages and disadvantages. Using advances in technologies of ODTs preparation, pharmaceutical companies can take Advantage of some of their product line extensions. Many studies have compared these dosage forms with ordinary tablets and found that ODTs have better patient compliance and biopharmaceutical properties. Not all conventional performance tests like the USP disintegration test are suitable to characterize this dosage form for its unique characteristics, and new tests need to be developed to capture critical dosage form attributes. This is especially important if an ODT is developed in a Quality by Design Approach.