Physical modification of Thai rice starch and its application as orodispersible film former

The objective of this study was to investigate the application of the physically modified rice starch (MRS) produced by alcoholic-alkaline (MRS-AA) and planetary ball-milling (MRS-BM) methods as an ODF film former. Rice starch was isolated from Thai rice grain. XRD and ATR-FTIR results confirmed crystallinity loss of MRS. MRS-AA exhibited prominently the greater swelling capacity, whereas MRS-BM exhibited prominently the greater cold water solubility.

Highlights

Application of physically modified starch as an ODF film former was explored for the first time.

Alcoholic-alkaline treatment resulted in modified rice starch with high swelling capacity, while ball-milling yielded the starch with greater cold water solubility.

Disintegration time of ODFs made of ball-milling < alcoholic-alkaline <<< native rice starch.

 

The starch-based orodispersible films (ODFs) with acceptable film and mechanical properties were successfully prepared using solvent casting method. MRS-based ODFs exhibited the greater flexible behaviors but lower disintegration time compared with the native system. Desloratadine loaded MRS-BM-based ODFs disintegrated within 62.3 ± 23.1 s, with more than 95% dissolution within 10 min. In conclusion, the ball-milling treatment resulted in the preferable MRS suitable for use as an ODF film former. This study therefore provides a glimpse into the use of physically modified starch as an ODF film former.

Continue reading on rice starch as orodispersible film former