Quality by Design in Pharmaceutical Development

18. June 2022

Design and formulation of an ideal pharmaceutical product is a tedious job for a formulator as it comprises multiple objectives....

Development of Nafamostat Mesylate Immediate-Release Tablet by Drug Repositioning Using Quality-by-Design Approach

15. June 2022

We aimed to develop nafamostat mesylate immediate-release tablets for the treatment of COVID-19 through drug repositioning studies of nafamostat mesylate...

QBD approach for the development of hesperetin loaded colloidal nanosponges for sustained delivery: In-vitro, ex-vivo, and in-vivo assessment

5. May 2022

Hesperetin (HT) is a polyphenolic compound with anti-carcinogenic, tumor necrosis, and anti-oxidant properties. The present study reports the fabrication, optimization,...

Quality by design-based optimization of formulation parameters to develop quercetin nanosuspension for improving its biopharmaceutical properties

29. April 2022

The present study describes the formulation, optimization and characterization of quercetin loaded nanosuspension. The formulation was prepared using liquid antisolvent...

A Quality by Design (QbD) study in direct compression using the most flowable microcrystalline cellulose CEOLUS™ UF-702

6. April 2022

OBJECTIVE CEOLUSTM UF-702 is the most flowable microcrystalline cellulose (MCC). While UF-702 has higher compactibility than standard grade PH-102, it...

Process Model Approach to Predict Tablet Weight Variability for Direct Compression Formulations at Pilot and Production Scale

27. March 2022

Optimizing processing conditions to achieve a critical quality attribute (CQA) is an integral part of pharmaceutical quality by design (QbD)....

Optimization of the Micellar-Based In Situ Gelling Systems Posaconazole with Quality by Design (QbD) Approach and Characterization by In Vitro Studies

4. March 2022

Background: Fungal ocular infections can cause serious consequences, despite their low incidence. It has been reported that Posaconazole (PSC) is...

QbD Approach towards Robust Design Space for Flutamide/Piperine Self-Emulsifying Drug Delivery System with Reduced Liver Injury

6. February 2022

Flutamide which is used to treat prostate cancer and other diseases induces liver damage during and after the therapy. The aim...

DOE in the development phase of orodispersible minitablets

Implementing the Design of Experiments (DoE) Concept into the Development Phase of Orodispersible Minitablets (ODMTs) Containing Melatonin

26. January 2022

Development of orodispersible minitablets (ODMTs) requires consideration of aspects related to small dimensions, while ensuring short disintegration time with sufficient...

Fig. 2. Unit operations in the direct compaction line including (a) loss-in-weight feeders and the continuous blender, (b) the tablet press with the ECVT powder mass flow measurement at the inlet and weigh scale-based tablet production rate measurement at the outlet, and (c) the hopper associated with the tablet press with a camera and image analysis-based level measurement system.

Real-Time Monitoring of Powder Mass Flowrates for Plant-Wide Control of a Continuous Direct Compaction Tablet Manufacturing Process

16. January 2022

While measurement and monitoring of powder/particulate mass flow rate are not essential to the execution of traditional batch pharmaceutical tablet...

Quality by Design (QbD)