QbD Approach towards Robust Design Space for Flutamide/Piperine Self-Emulsifying Drug Delivery System with Reduced Liver Injury

6. February 2022

Flutamide which is used to treat prostate cancer and other diseases induces liver damage during and after the therapy. The aim...

DOE in the development phase of orodispersible minitablets

Implementing the Design of Experiments (DoE) Concept into the Development Phase of Orodispersible Minitablets (ODMTs) Containing Melatonin

26. January 2022

Development of orodispersible minitablets (ODMTs) requires consideration of aspects related to small dimensions, while ensuring short disintegration time with sufficient...

Fig. 2. Unit operations in the direct compaction line including (a) loss-in-weight feeders and the continuous blender, (b) the tablet press with the ECVT powder mass flow measurement at the inlet and weigh scale-based tablet production rate measurement at the outlet, and (c) the hopper associated with the tablet press with a camera and image analysis-based level measurement system.

Real-Time Monitoring of Powder Mass Flowrates for Plant-Wide Control of a Continuous Direct Compaction Tablet Manufacturing Process

16. January 2022

While measurement and monitoring of powder/particulate mass flow rate are not essential to the execution of traditional batch pharmaceutical tablet...

Streamlining the development of an industrial dry granulation process for an immediate release tablet with systems modelling

29. December 2021

In industrial practice, the development of pharmaceutical dry granulation processes typically involves time- and resource-intensive multivariate experiments. These experiments are...

graphical abstract of High shear wet granulation: Improved understanding of the effects of process variables on granule and tablet properties of a high-dose, high-hydrophobicity API based on quality by design and multivariate analysis approaches

High shear wet granulation: Improved understanding of the effects of process variables on granule and tablet properties of a high-dose, high-hydrophobicity API based on quality by design and multivariate analysis approaches

12. December 2021

High shear wet granulation (HSWG), as a widely used granulation technology, has been studied extensively. However, for the HSWG of...

graphical abstract of An update on microcrystalline cellulose in direct compression: Functionality, critical material attributes, and co-processed excipients

An update on microcrystalline cellulose in direct compression: Functionality, critical material attributes, and co-processed excipients

11. December 2021

Microcrystalline cellulose (MCC) is one of the most popular cellulose derivatives in the pharmaceutical industry. Thanks to its outstanding tabletability,...

graphical abstract of Control Strategy for Process Development of High-Shear Wet Granulation and Roller Compaction to Prepare a Combination Drug Using Integrated Quality by Design

Control Strategy for Process Development of High-Shear Wet Granulation and Roller Compaction to Prepare a Combination Drug Using Integrated Quality by Design

7. December 2021

In this study, we developed a control strategy for a drug product prepared by high-shear wet granulation and roller compaction...

Quality by Design applied to the development of soft gelatin capsules

29. November 2021

The pandemic we are experiencing made us realize the impact and need for medication in patients' lives. These, in turn,...

Figure 1. Pictorial representation of the progression of quality by design model

Explicating the Applications of Quality by Design Tools in Optimization of Microparticles and Nanotechnology Based Drug Delivery Systems

25. November 2021

Quality by design (QbD) can also contribute to design, manufacturing, and producing highly finished goods. To better explain the manufacturing...

QbD steered fabrication of Pullulan-Terminalia catappa-Carbopol®971P film forming gel for improved rheological, textural and biopharmaceutical aspects

2. November 2021

In present work, a film forming gel (FFG) was developed through ingenious amalgamation of polymers: Pullulan, Terminalia catappa and Carbopol®971P ® for...

Quality by Design (QbD)