Solubility Enhancement

Excipients are major components of oral solid dosage forms, and changes in their critical material attributes (excipient variability) and/or amount...

Hot melt extrusion is a promising technology for producing amorphous solid dispersions, however, there is a risk of thermal degradation...

The formation of solid dispersions with the amorphous drug dispersed in the polymeric matrix improves the dissolution characteristics of poorly...

Highlights • Soluplus® could be used as a carrier for the entrapment of SEDDS. • Spray drying is efficient for...

Silymarin, a mixture of flavonolignan and flavonoid polyphenolic compounds extractable from milk thistle (Silybum marianum) seeds, is gaining an increasingly...

Ferulic acid, though used in formulations of skin-care and cosmetic products, suffers from the problems of poor stability and low...

Antibiotic resistance has become a global crisis, driving the exploration for novel antibiotics and novel treatment approaches. Among these research...

Simple solvent shift is often used to induce supersaturation and investigate precipitation kinetics in early drug development as a substitute...

Isomalt is a polyol derived from sucrose. Advantages of this excipient are its sweet taste, which is supposed to allow...

Fenretinide (4-HPR), as a semi-synthetic retinoid, has apoptosis-promoting effects as a single agent and chemotherapy synergist in vitro. When a human...