Thermodynamic Aspects of the Preparation of Amorphous Solid Dispersions of Naringenin with Enhanced Dissolution Rate

28. April 2020

Amorphous ternary solid dispersions of poorly water-soluble Naringenin (NRG) in Poloxamer 188 (POX) and Neusilin US2 (NSL) were prepared in...

Influence of Carbamazepine Dihydrate on the Preparation of Amorphous Solid Dispersions by Hot Melt Extrusion

27. April 2020

Amorphous solid dispersions (ASDs) are commonly used in the pharmaceutical industry to improve the dissolution and bioavailability of poorly water-soluble...

Enhanced dissolution, permeation and oral bioavailability of aripiprazole mixed micelles

27. April 2020

Aripiprazole (ARP) is an antipsychotic drug approved for the treatment of schizophrenia. It is poorly water-soluble and undergoes extensive hepatic...

Influence of Formulation Parameters on Redispersibility of Naproxen Nanoparticles from Granules Produced in a Fluidized Bed Process

22. April 2020

The particle size reduction of active pharmaceutical ingredients is an efficient method to overcome challenges associated with a poor aqueous...

Activation energy diagram for the solubilization of a drug from a crystalline form

Improved Dissolution and Pharmacokinetics of Abiraterone through KinetiSol® Enabled Amorphous Solid Dispersions

21. April 2020

Abiraterone is a poorly water-soluble drug. It has a high melting point and limited solubility in organic solvents, making it...

Pharmacological treatment of hyperglycemia according to site of action

The manufacture of fixed dose combination products using advanced pharmaceutical techniques for the treatment of cardiovascular disease and type II diabetes

21. April 2020

Thesis by Jeremiah Kelleher, School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, The University of Dublin The thesis has focused on...

multicomponent-solid-dispersion-produced-by-spray-drying

Multicomponent solid dispersion: A new generation of solid dispersion produced by spray-drying

20. April 2020

The term “multicomponent solid dispersion” is widely used in recent literature to describe solid formulations consisting of a special excipient's...

Preclinical evaluation of new formulation concepts for abiraterone acetate bioavailability enhancement based on the inhibition of pH-induced precipitation

18. April 2020

Abiraterone acetate is a potent drug used for the treatment of metastatic castration resistant prostate cancer. However, currently marketed product...

New Delivery Method Could Make Niclosamide an Effective Antiviral to Treat COVID-19

11. April 2020

Repurposing drugs such as the FDA-approved niclosamide is a highly efficient way to leverage drugs with known safety profiles to...

Novel interpenetrating polymeric network based microbeads for delivery of poorly water soluble drug

11. April 2020

A well-designed drug delivery platform improves the pharmacological properties of therapeutics. Here, we report a biodegradable interpenetrating polymer network (IPN)...

Solubility Enhancement