Advanced formulations “supersaturating drug delivery systems” – A video by UNGAP

An UNGAP video further focussing on specific intraluminal behavior of advanced formulations such as supersaturating drug delivery systems, nanoparticles, and lipid-based and controlled release formulations.

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Oral administration is the most common drug delivery route. Absorption of a drug from the gut into the bloodstream involves disintegration of the dosage form, dissolution of the API, and transport across the gut wall. The efficiency of these processes is determined by highly complex and dynamic interactions between the gastrointestinal tract, the dosage form and the API.The fraction absorbed of the drug is affected by various factors including physiological variables, pathological conditions, local differences in gut permeability, the intraluminal behaviour of the formulation, and food effects. This complex interplay determines drug delivery performance and may cause large interindividual variability, but is poorly understood. Furthermore, comparison between drug absorption studies is hampered due to knowledge fragmentation and lack of standardisation across pharmaceutical subdisciplines. As a result, the available knowledge is underutilized in drug development and clinical treatment.The European Network on Understanding Gastrointestinal Absorption-related Processes (UNGAP) is a multidisciplinary Network of scientists aiming to advance the field of intestinal drug absorption by focussing on 4 major challenges: (i) differences between specific patient populations, (ii) regional differences along the gastrointestinal tract, (iii) the intraluminal behaviour of advanced formulations, and (iv) the food-drug interface. The integration of knowledge, combined with the exchange of best practices across sectors and disciplines, will help improve our understanding of intestinal drug absorption and spur future developments in the field. The Action also aims to advance the career of young, talented researchers from across Europe, thereby strengthening Europe’s leading position in pharmaceutical sciences. More

Amorphous Solid Dispersions – Ask A Specialist!

More and more poorly water-soluble or even water-insoluble drug candidates show up in pharmaceutical development. Achieving a good bioavailability and efficacy requires technical platforms and processes. Solid dispersions and amorphous solid dispersions are well established and proven approaches to overcome the API solubility issue.

We did a well-attended webcast on this topic with the expert Dr. Norbert Pöllinger from Glatt Pharmaceutical Services. He presented Glatt’s tools and technology platforms and answered a lot of questions related to amorphous solid dispersion.

To share this knowledge with the excipients community we made some composites of the video. Also you can view the full recording for free – access here