Solubility Enhancement

Abstract The oral bioavailability and therapeutic efficacy of a compound are largely determined by its aqueous solubility and interfacial partitioning....

Dispersome is a solubility enhancement technology that relies on an innovative and naturally occurring excipient to develop amorphous solid dispersions...

Abstract Purpose This study aims to evaluate the ability of various cyclodextrins (CDs) to enhance the aqueous solubility of haloperidol...

Abstract Introduction: The cold-burst method presents a novel, energy-efficient, and cost-effective approach for solid lipid nanoparticle (SLN) production compared to...

Press Release January 23, 2025 COPENHAGEN, Denmark: Zerion Pharma A/S (“ZERION”) today announces a partnership with Aché Laboratorios Farmacêuticos S.A....

Abstract This study investigates the solubility and miscibility of ibuprofen (IBU) with four pharmaceutical polymers, KOLVA64®, KOL17PF®, HPMCAS, and Eudragit®...

Oral drug delivery to the colon remains a formidable challenge due to the harsh conditions of the upper gastrointestinal tract,...

Abstract This study introduced a novel vectorized Biopharmaceutics Classification System (BCS) model designed to evaluate the biopharmaceutical properties of active...

Abstract Polyethoxylated (PEO)-based nonionic surfactants, such as D-α-Tocopheryl polyethylene glycol succinate (TPGS), offer significant advantages in drug delivery due to...

Abstract Amorphous solid dispersions (ASDs) make a significant contribution to enhancing the solubility of poorly soluble drugs. The incorporation of...